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Ptprt protein tyrosine phosphatase, receptor type, T [ Rattus norvegicus (Norway rat) ]

Gene ID: 362263, updated on 8-Apr-2026
Symbol
Ptprtprovided by RGD
Full Name
protein tyrosine phosphatase, receptor type, Tprovided by RGD
Primary source
RGD:1309653
See related
Ensembl:ENSRNOG00000032656 AllianceGenome:RGD:1309653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including STAT family protein binding activity; alpha-catenin binding activity; and beta-catenin binding activity. Involved in regulation of synapse organization. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in colorectal cancer and esophagus squamous cell carcinoma. Orthologous to human PTPRT (protein tyrosine phosphatase receptor type T). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 112.0), Spleen (RPKM 11.2) and 1 other tissue See more
Orthologs
all
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Try the new Transcripts and proteins table
See Ptprt in Genome Data Viewer
Location:
3q42
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (170608993..171707692, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (150189343..151288145, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (157537192..158328984, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350515 Neighboring gene uncharacterized LOC120101777 Neighboring gene uncharacterized LOC134486201 Neighboring gene U2 small nuclear ribonucleoprotein B''-like Neighboring gene uncharacterized LOC120101926 Neighboring gene uncharacterized LOC120101925 Neighboring gene uncharacterized LOC134486308 Neighboring gene uncharacterized LOC102547303

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. PTPRT and PTPRD Deleterious Mutations and Deletion Predict Bevacizumab Resistance in Metastatic Colorectal Cancer Patients. Hsu HC, et al. Cancers (Basel), 2018 Sep 6. PMID 30200630, Free PMC Article
  2. Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis. Zhao Y, et al. Oncotarget, 2017 Jul 25. PMID 27447856, Free PMC Article
  3. The Functional Variant in the 3'UTR of PTPRT with the Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population. Yao Y, et al. Cell Physiol Biochem, 2015. PMID 25967969
  4. Tumor-derived extracellular mutations of PTPRT /PTPrho are defective in cell adhesion. Yu J, et al. Mol Cancer Res, 2008 Jul. PMID 18644975, Free PMC Article
  5. PTPRT regulates the interaction of Syntaxin-binding protein 1 with Syntaxin 1 through dephosphorylation of specific tyrosine residue. Lim SH, et al. Biochem Biophys Res Commun, 2013 Sep 13. PMID 23962429

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTPRT could regulate the interaction of Syntaxin-binding protein 1 with Syntaxin 1, and as a result, the synaptic vesicle fusion appears to be controlled through dephosphorylation of Syntaxin-binding protein 1
    Title: PTPRT regulates the interaction of Syntaxin-binding protein 1 with Syntaxin 1 through dephosphorylation of specific tyrosine residue.
  2. BCR is a novel substrate of PTPRT .
    Title: Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables STAT family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
  
enables alpha-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
  
enables delta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables thiolester hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane receptor protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interleukin-6 ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of receptor signaling pathway via STAT ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
receptor-type tyrosine-protein phosphatase T
NP_001102073.2
NP_001388938.1
XP_038961463.1
XP_038961464.1
XP_038961465.1
XP_038961467.1
XP_038961468.1
XP_063140269.1
XP_063140270.1
XP_063140271.1
XP_063140272.1
XP_063140273.1
XP_063140274.1
XP_063140275.1
XP_063140276.1
XP_063140277.1
XP_063140278.1
XP_063140279.1
XP_063140280.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108603.3 → NP_001102073.2  receptor-type tyrosine-protein phosphatase T isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JX03

  2. NM_001402009.2 → NP_001388938.1  receptor-type tyrosine-protein phosphatase T isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0ABK0M3K7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    170608993..171707692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105540.2 → XP_038961468.1  receptor-type tyrosine-protein phosphatase T isoform X16

    UniProtKB/TrEMBL
    A0ABK0LFL0
    Related
    ENSRNOP00000109490.1, ENSRNOT00000163556.1
    Conserved Domains (7) summary
    smart00137
    Location:36 → 193
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00063
    Location:394 → 484
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14630
    Location:904 → 1140
    R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1
    cd14634
    Location:1225 → 1430
    R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2
    pfam00041
    Location:506 → 581
    fn3; Fibronectin type III domain
    pfam18861
    Location:674 → 776
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
    cl11960
    Location:200 → 285
    Ig; Immunoglobulin domain

  2. XM_039105536.2 → XP_038961464.1  receptor-type tyrosine-protein phosphatase T isoform X12

    UniProtKB/TrEMBL
    A0A8I6AFL3, A0ABK0M3K7
    Related
    ENSRNOP00000091531.1, ENSRNOT00000102150.2
    Conserved Domains (7) summary
    smart00137
    Location:36 → 193
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00063
    Location:394 → 484
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14630
    Location:904 → 1160
    R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1
    cd14634
    Location:1245 → 1450
    R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2
    pfam00041
    Location:506 → 581
    fn3; Fibronectin type III domain
    pfam18861
    Location:674 → 776
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
    cl11960
    Location:200 → 285
    Ig; Immunoglobulin domain

  3. XM_039105539.2 → XP_038961467.1  receptor-type tyrosine-protein phosphatase T isoform X15

    UniProtKB/TrEMBL
    A0ABK0M3K7
    Conserved Domains (7) summary
    smart00137
    Location:36 → 193
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00063
    Location:394 → 484
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14630
    Location:913 → 1149
    R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1
    cd14634
    Location:1234 → 1439
    R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2
    pfam00041
    Location:506 → 581
    fn3; Fibronectin type III domain
    pfam18861
    Location:674 → 776
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
    cl11960
    Location:200 → 285
    Ig; Immunoglobulin domain

  4. XM_063284208.1 → XP_063140278.1  receptor-type tyrosine-protein phosphatase T isoform X11

    UniProtKB/TrEMBL
    A0ABK0M3K7

  5. XM_063284207.1 → XP_063140277.1  receptor-type tyrosine-protein phosphatase T isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZW41, A0ABK0M3K7
    Related
    ENSRNOP00000083869.1, ENSRNOT00000102159.2

  6. XM_063284205.1 → XP_063140275.1  receptor-type tyrosine-protein phosphatase T isoform X7

    UniProtKB/TrEMBL
    A0ABK0M3K7

  7. XM_063284209.1 → XP_063140279.1  receptor-type tyrosine-protein phosphatase T isoform X14

    UniProtKB/TrEMBL
    A0ABK0M3K7

  8. XM_039105537.2 → XP_038961465.1  receptor-type tyrosine-protein phosphatase T isoform X13

    UniProtKB/TrEMBL
    A0ABK0M3K7
    Conserved Domains (6) summary
    smart00137
    Location:36 → 193
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00063
    Location:394 → 484
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14630
    Location:923 → 1159
    R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1
    cd14634
    Location:1244 → 1449
    R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2
    pfam00041
    Location:506 → 581
    fn3; Fibronectin type III domain
    cl11960
    Location:200 → 285
    Ig; Immunoglobulin domain

  9. XM_063284204.1 → XP_063140274.1  receptor-type tyrosine-protein phosphatase T isoform X6

    UniProtKB/TrEMBL
    A0ABK0M3K7

  10. XM_063284203.1 → XP_063140273.1  receptor-type tyrosine-protein phosphatase T isoform X5

    UniProtKB/TrEMBL
    A0ABK0M3K7

  11. XM_063284201.1 → XP_063140271.1  receptor-type tyrosine-protein phosphatase T isoform X3

    UniProtKB/TrEMBL
    A0ABK0M3K7

  12. XM_039105535.2 → XP_038961463.1  receptor-type tyrosine-protein phosphatase T isoform X10

    UniProtKB/TrEMBL
    A0ABK0M3K7, F1LXJ9
    Related
    ENSRNOP00000041324.5, ENSRNOT00000044466.6
    Conserved Domains (6) summary
    smart00137
    Location:36 → 193
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00063
    Location:394 → 484
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14630
    Location:933 → 1169
    R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1
    cd14634
    Location:1254 → 1459
    R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2
    pfam00041
    Location:506 → 581
    fn3; Fibronectin type III domain
    cl11960
    Location:200 → 285
    Ig; Immunoglobulin domain

  13. XM_063284202.1 → XP_063140272.1  receptor-type tyrosine-protein phosphatase T isoform X4

    UniProtKB/TrEMBL
    A0ABK0M3K7
    Related
    ENSRNOP00000111622.1, ENSRNOT00000141984.1

  14. XM_063284200.1 → XP_063140270.1  receptor-type tyrosine-protein phosphatase T isoform X2

    UniProtKB/TrEMBL
    A0ABK0M3K7

  15. XM_063284206.1 → XP_063140276.1  receptor-type tyrosine-protein phosphatase T isoform X8

    UniProtKB/TrEMBL
    A0ABK0M3K7

  16. XM_063284199.1 → XP_063140269.1  receptor-type tyrosine-protein phosphatase T isoform X1

    UniProtKB/TrEMBL
    A0ABK0M3K7

  17. XM_063284210.1 → XP_063140280.1  receptor-type tyrosine-protein phosphatase T isoform X17

Nucleotide Protein Strain
Heading Accession and Version

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