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Mpped2 metallophosphoesterase domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362185, updated on 8-Apr-2026
Official Symbol
Mpped2provided by RGD
Official Full Name
metallophosphoesterase domain containing 2provided by RGD
Primary source
RGD:735060
See related
Ensembl:ENSRNOG00000004863 AllianceGenome:RGD:735060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
C11orf8; C11orf8h
Summary
Enables manganese ion binding activity; phosphoric diester hydrolase activity; and purine ribonucleotide binding activity. Orthologous to human MPPED2 (metallophosphoesterase domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 25.5), Adrenal (RPKM 18.3) and 8 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Mpped2 in Genome Data Viewer
Location:
3q33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (113635614..113810307)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (93180895..93355605)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (97720308..97899735)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C24 Neighboring gene doublecortin domain containing 1, pseudogene 1 Neighboring gene doublecortin domain containing 1 Neighboring gene histidine triad nucleotide binding protein 1, pseudogene 4 Neighboring gene ARF like GTPase 14 effector protein Neighboring gene follicle stimulating hormone subunit beta

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Unique utilization of a phosphoprotein phosphatase fold by a mammalian phosphodiesterase associated with WAGR syndrome. Dermol U, et al. J Mol Biol, 2011 Sep 23. PMID 21824479
  2. A WAGR region gene between PAX-6 and FSHB expressed in fetal brain. Schwartz F, et al. Hum Genet, 1994 Dec. PMID 7527372
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables AMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclic-nucleotide phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoric diester hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
metallophosphoesterase MPPED2
Names
239FB
fetal brain protein 239 homolog
metallophosphoesterase domain-containing protein 2
putative C11orf8 homolog

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198778.3 → NP_942073.2  metallophosphoesterase MPPED2

    See identical proteins and their annotated locations for NP_942073.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    B1WBP0, Q8CFG1
    UniProtKB/TrEMBL
    A0A8L2R9I0
    Related
    ENSRNOP00000062716.1, ENSRNOT00000065168.4
    Conserved Domains (2) summary
    cd07379
    Location:59 → 271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
    pfam00149
    Location:59 → 255
    Metallophos; Calcineurin-like phosphoesterase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    113635614..113810307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234683.5 → XP_006234745.1  metallophosphoesterase MPPED2 isoform X1

    See identical proteins and their annotated locations for XP_006234745.1

    UniProtKB/Swiss-Prot
    B1WBP0, Q8CFG1
    UniProtKB/TrEMBL
    A0A8L2R9I0
    Conserved Domains (2) summary
    cd07379
    Location:59 → 271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
    pfam00149
    Location:59 → 255
    Metallophos; Calcineurin-like phosphoesterase

  2. XM_006234682.5 → XP_006234744.1  metallophosphoesterase MPPED2 isoform X1

    See identical proteins and their annotated locations for XP_006234744.1

    UniProtKB/Swiss-Prot
    B1WBP0, Q8CFG1
    UniProtKB/TrEMBL
    A0A8L2R9I0
    Conserved Domains (2) summary
    cd07379
    Location:59 → 271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
    pfam00149
    Location:59 → 255
    Metallophos; Calcineurin-like phosphoesterase

  3. XM_006234681.5 → XP_006234743.1  metallophosphoesterase MPPED2 isoform X1

    See identical proteins and their annotated locations for XP_006234743.1

    UniProtKB/Swiss-Prot
    B1WBP0, Q8CFG1
    UniProtKB/TrEMBL
    A0A8L2R9I0
    Conserved Domains (2) summary
    cd07379
    Location:59 → 271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
    pfam00149
    Location:59 → 255
    Metallophos; Calcineurin-like phosphoesterase

  4. XM_039105449.2 → XP_038961377.1  metallophosphoesterase MPPED2 isoform X2

    UniProtKB/TrEMBL
    A6HNZ1
    Conserved Domains (1) summary
    cd07379
    Location:72 → 145
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

  5. XM_039105448.2 → XP_038961376.1  metallophosphoesterase MPPED2 isoform X2

    UniProtKB/TrEMBL
    A6HNZ1
    Conserved Domains (1) summary
    cd07379
    Location:72 → 145
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1WBP0.1 GenPept UniProtKB/Swiss-Prot:B1WBP0

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