Format

Send to:

Choose Destination

ING1 inhibitor of growth family member 1 [ Homo sapiens (human) ]

Gene ID: 3621, updated on 7-Jun-2020

Summary

Official Symbol
ING1provided by HGNC
Official Full Name
inhibitor of growth family member 1provided by HGNC
Primary source
HGNC:HGNC:6062
See related
Ensembl:ENSG00000153487 MIM:601566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p33; p47; p33ING1; p24ING1c; p33ING1b; p47ING1a
Summary
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 5.0), endometrium (RPKM 4.3) and 25 other tissues See more
Orthologs

Genomic context

See ING1 in Genome Data Viewer
Location:
13q34
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (110712623..110723339)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (111364970..111373421)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RAB20, member RAS oncogene family Neighboring gene NAD(P)HX dehydratase Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene uncharacterized LOC107984613 Neighboring gene ribosomal protein L21 pseudogene 107

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
inhibitor of growth protein 1
Names
growth inhibitor ING1
growth inhibitory protein ING1
tumor suppressor ING1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012197.1 RefSeqGene

    Range
    4888..13339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267728.1NP_001254657.1  inhibitor of growth protein 1 isoform E

    See identical proteins and their annotated locations for NP_001254657.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an internal segment in the 5' coding region, compared to variant 4. The resulting isoform (E) lacks an internal segment, as compared to isoform D.
    Source sequence(s)
    AB037594, BC018348, DB537640
    UniProtKB/Swiss-Prot
    Q9UK53
    Conserved Domains (2) summary
    cd15584
    Location:195239
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    pfam12998
    Location:2994
    ING; Inhibitor of growth proteins N-terminal histone-binding
  2. NM_005537.5NP_005528.4  inhibitor of growth protein 1 isoform D

    See identical proteins and their annotated locations for NP_005528.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (D).
    Source sequence(s)
    AI016573, AL157820, BC018348, KF455830
    Consensus CDS
    CCDS9517.1
    UniProtKB/Swiss-Prot
    Q9UK53
    UniProtKB/TrEMBL
    A0A0C4DFW2
    Related
    ENSP00000364929.3, ENST00000375774.3
    Conserved Domains (2) summary
    cd15584
    Location:355399
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    pfam12998
    Location:189254
    ING; Inhibitor of growth proteins N-terminal histone-binding
  3. NM_198217.2NP_937860.1  inhibitor of growth protein 1 isoform C

    See identical proteins and their annotated locations for NP_937860.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' end-region, which includes part of the coding region, compared to variant 4. The resulting isoform (C) has a shorter N-terminus, as compared to isoform D.
    Source sequence(s)
    AF181850, AK302353, BC018348, DB450867, DB537640
    Consensus CDS
    CCDS9515.1
    UniProtKB/Swiss-Prot
    Q9UK53
    Related
    ENSP00000345202.7, ENST00000338450.7
    Conserved Domains (2) summary
    cd15584
    Location:168212
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    pfam12998
    Location:267
    ING; Inhibitor of growth proteins N-terminal histone-binding
  4. NM_198218.2NP_937861.1  inhibitor of growth protein 1 isoform B

    See identical proteins and their annotated locations for NP_937861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' end-region and uses a downstream in-frame start codon, compared to variant 4. The resulting isoform (B) has a shorter N-terminus, as compared to isoform D.
    Source sequence(s)
    AF181850, BC018348, BG703874, BQ430264, DB537640
    Consensus CDS
    CCDS9518.1
    UniProtKB/Swiss-Prot
    Q9UK53
    Related
    ENSP00000364930.3, ENST00000375775.3
    Conserved Domains (2) summary
    cd15584
    Location:143187
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    cl26267
    Location:242
    ING; Inhibitor of growth proteins N-terminal histone-binding
  5. NM_198219.3NP_937862.1  inhibitor of growth protein 1 isoform A

    See identical proteins and their annotated locations for NP_937862.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' end-region, which includes part of the coding region, compared to variant 4. The resulting isoform (A) has a distinct and shorter N-terminus, as compared to isoform D.
    Source sequence(s)
    AL157820
    Consensus CDS
    CCDS9516.1
    UniProtKB/Swiss-Prot
    Q9UK53
    Related
    ENSP00000328436.7, ENST00000333219.8
    Conserved Domains (2) summary
    cd15584
    Location:212256
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    pfam12998
    Location:15111
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    110712623..110723339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center