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Agl amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 362029, updated on 17-Nov-2020

Summary

Official Symbol
Aglprovided by RGD
Official Full Name
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferaseprovided by RGD
Primary source
RGD:1306376
See related
Ensembl:ENSRNOG00000016214
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Muscle (RPKM 1109.1), Heart (RPKM 209.7) and 2 other tissues See more
Orthologs

Genomic context

See Agl in Genome Data Viewer
Location:
2q41
Exon count:
34
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219788234..219843189, complement)
106 current Rn_Celera (GCF_000002265.2) 2 AC_000070.1 (197196717..197252494, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (237375913..237430811)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548510 Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene solute carrier family 35 member A3 Neighboring gene phospholipid phosphatase related 5 Neighboring gene uncharacterized LOC108348210 Neighboring gene phospholipid phosphatase related 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
4-alpha-glucanotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
4-alpha-glucanotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
4-alpha-glucanotransferase activity ISO
Inferred from Sequence Orthology
more info
 
amylo-alpha-1,6-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amylo-alpha-1,6-glucosidase activity IDA
Inferred from Direct Assay
more info
PubMed 
amylo-alpha-1,6-glucosidase activity ISO
Inferred from Sequence Orthology
more info
 
beta-maltose 4-alpha-glucanotransferase activity IEA
Inferred from Electronic Annotation
more info
 
carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
glycogen debranching enzyme activity ISO
Inferred from Sequence Orthology
more info
 
polysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
glycogen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycogen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
 
response to glucocorticoid IDA
Inferred from Direct Assay
more info
PubMed 
response to hormone IDA
Inferred from Direct Assay
more info
PubMed 
response to nutrient IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
inclusion body ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glycogen debranching enzyme
Names
amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (glycogen debranching enzyme, glycogen storage disease type III)
amylo-1,6-glucosidase, 4-alpha-glucanotransferase
NP_001102034.1
XP_006233291.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108564.1NP_001102034.1  glycogen debranching enzyme

    See identical proteins and their annotated locations for NP_001102034.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473952
    UniProtKB/TrEMBL
    D4AEH9
    Related
    ENSRNOP00000052593.2, ENSRNOT00000055735.2
    Conserved Domains (5) summary
    cd11327
    Location:105583
    AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
    TIGR01531
    Location:221532
    glyc_debranch; glycogen debranching enzymye
    pfam06202
    Location:10731527
    GDE_C; Amylo-alpha-1,6-glucosidase
    pfam14699
    Location:31116
    hGDE_N; N-terminal domain from the human glycogen debranching enzyme
    pfam14702
    Location:697974
    hGDE_central; central domain of human glycogen debranching enzyme

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    219788234..219843189 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233229.3XP_006233291.1  glycogen debranching enzyme isoform X1

    See identical proteins and their annotated locations for XP_006233291.1

    UniProtKB/TrEMBL
    D4AEH9
    Conserved Domains (5) summary
    cd11327
    Location:105583
    AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
    TIGR01531
    Location:221532
    glyc_debranch; glycogen debranching enzymye
    pfam06202
    Location:10731527
    GDE_C; Amylo-alpha-1,6-glucosidase
    pfam14699
    Location:31116
    hGDE_N; N-terminal domain from the human glycogen debranching enzyme
    pfam14702
    Location:697974
    hGDE_central; central domain of human glycogen debranching enzyme

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    197196717..197252494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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