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Fga fibrinogen alpha chain [ Rattus norvegicus (Norway rat) ]

Gene ID: 361969, updated on 10-Oct-2019

Summary

Official Symbol
Fgaprovided by RGD
Official Full Name
fibrinogen alpha chainprovided by RGD
Primary source
RGD:2603
See related
Ensembl:ENSRNOG00000024848
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fba5e; Ac1873
Summary
plays a role in blood coagulation; may be involved in liver regeneration [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 13599.1) See more
Orthologs

Genomic context

See Fga in Genome Data Viewer
Location:
2q34
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (181997562..182013726)
106 current Rn_Celera (GCF_000002265.2) 2 AC_000070.1 (162392064..162408023)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (201412182..201428346)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556113 Neighboring gene fibrinogen gamma chain Neighboring gene fibrinogen beta chain Neighboring gene pleiotropic regulator 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC156536

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to signaling receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
structural molecule activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acute-phase response IEP
Inferred from Expression Pattern
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
blood coagulation ISO
Inferred from Sequence Orthology
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
PubMed 
blood coagulation, common pathway IEA
Inferred from Electronic Annotation
more info
 
blood coagulation, common pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
blood coagulation, fibrin clot formation ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to granulocyte colony-stimulating factor IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interleukin-6 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
envenomation resulting in modulation of blood coagulation in other organism IEP
Inferred from Expression Pattern
more info
PubMed 
fibrinolysis IEA
Inferred from Electronic Annotation
more info
 
fibrinolysis ISO
Inferred from Sequence Orthology
more info
PubMed 
induction of bacterial agglutination IEA
Inferred from Electronic Annotation
more info
 
induction of bacterial agglutination ISO
Inferred from Sequence Orthology
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
PubMed 
plasminogen activation IEA
Inferred from Electronic Annotation
more info
 
plasminogen activation ISO
Inferred from Sequence Orthology
more info
PubMed 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
platelet aggregation IEA
Inferred from Electronic Annotation
more info
 
platelet aggregation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of exocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of peptide hormone secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptide hormone secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
PubMed 
protein polymerization IEA
Inferred from Electronic Annotation
more info
 
protein polymerization ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
response to X-ray IEP
Inferred from Expression Pattern
more info
PubMed 
response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
response to calcium ion ISO
Inferred from Sequence Orthology
more info
PubMed 
response to cycloheximide IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to genistein IEP
Inferred from Expression Pattern
more info
PubMed 
response to growth hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
response to morphine IEP
Inferred from Expression Pattern
more info
PubMed 
response to thyroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
blood microparticle IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
fibrinogen complex IEA
Inferred from Electronic Annotation
more info
 
fibrinogen complex ISO
Inferred from Sequence Orthology
more info
PubMed 
platelet alpha granule IEA
Inferred from Electronic Annotation
more info
 
platelet alpha granule ISO
Inferred from Sequence Orthology
more info
PubMed 
rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
fibrinogen alpha chain
Names
fibrinogen, A alpha polypeptide
fibrinogen, alpha polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008724.1NP_001008724.1  fibrinogen alpha chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_001008724.1

    Status: PROVISIONAL

    Source sequence(s)
    AY310161
    UniProtKB/TrEMBL
    Q7TQ70
    Conserved Domains (3) summary
    cd00087
    Location:546779
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam08702
    Location:51189
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam12160
    Location:388453
    Fibrinogen_aC; Fibrinogen alpha C domain
  2. NM_052797.1NP_434684.1  fibrinogen alpha chain isoform 2 precursor

    See identical proteins and their annotated locations for NP_434684.1

    Status: PROVISIONAL

    Source sequence(s)
    BC127465
    UniProtKB/TrEMBL
    A1L114
    Conserved Domains (2) summary
    pfam08702
    Location:51189
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam12160
    Location:388453
    Fibrinogen_aC; Fibrinogen alpha C domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    181997562..182013726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232533.3XP_006232595.1  fibrinogen alpha chain isoform X2

    See identical proteins and their annotated locations for XP_006232595.1

    UniProtKB/TrEMBL
    Q7TQ70
    Related
    ENSRNOP00000060007.2, ENSRNOT00000064091.3
    Conserved Domains (3) summary
    cd00087
    Location:546779
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam08702
    Location:51189
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam12160
    Location:388453
    Fibrinogen_aC; Fibrinogen alpha C domain
  2. XM_006232532.3XP_006232594.1  fibrinogen alpha chain isoform X1

    Conserved Domains (3) summary
    cd00087
    Location:549782
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam08702
    Location:54192
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam12160
    Location:391456
    Fibrinogen_aC; Fibrinogen alpha C domain

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    162392064..162408023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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