U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Actl6a actin-like 6A [ Rattus norvegicus (Norway rat) ]

Gene ID: 361925, updated on 13-Oct-2022

Summary

Official Symbol
Actl6aprovided by RGD
Official Full Name
actin-like 6Aprovided by RGD
Primary source
RGD:1307747
See related
Ensembl:ENSRNOG00000011553 AllianceGenome:RGD:1307747
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307747
Summary
Predicted to enable chromatin binding activity. Involved in spinal cord development. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of NuA4 histone acetyltransferase complex and chromatin. Orthologous to human ACTL6A (actin like 6A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 177.6), Spleen (RPKM 116.7) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Actl6a in Genome Data Viewer
Location:
2q24
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (115492374..115508401)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (119112776..119128870)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546477 Neighboring gene uncharacterized LOC120100797 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene mitochondrial ribosomal protein L47 Neighboring gene NADH:ubiquinone oxidoreductase subunit B5 Neighboring gene small nucleolar RNA SNORA70

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC112664

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H2A acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H4 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H4 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in neural retina development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spinal cord development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
 
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
part_of npBAF complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039033.1NP_001034122.1  actin-like protein 6A

    See identical proteins and their annotated locations for NP_001034122.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098698
    UniProtKB/TrEMBL
    D3ZJJ2, Q4KM87
    Related
    ENSRNOP00000015460.6, ENSRNOT00000015460.8
    Conserved Domains (1) summary
    pfam00022
    Location:11429
    Actin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    115492374..115508401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232253.3XP_006232315.1  actin-like protein 6A isoform X1

    See identical proteins and their annotated locations for XP_006232315.1

    Conserved Domains (1) summary
    pfam00022
    Location:7377
    Actin