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INCENP inner centromere protein [ Homo sapiens (human) ]

Gene ID: 3619, updated on 7-Dec-2018

Summary

Official Symbol
INCENPprovided by HGNC
Official Full Name
inner centromere proteinprovided by HGNC
Primary source
HGNC:HGNC:6058
See related
Ensembl:ENSG00000149503 MIM:604411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 6.2), esophagus (RPKM 5.2) and 24 other tissues See more
Orthologs

Genomic context

See INCENP in Genome Data Viewer
Location:
11q12.3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (62123973..62155474)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61891445..61920635)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene 37 Neighboring gene uncharacterized LOC100507521 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 8 Neighboring gene secretoglobin family 1D member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
NHGRI GWA Catalog
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates INCENP in HeLa cells within 12 hours of exposure PubMed
vpr HIV-1 Vpr interferes with the heterochromatin structure by displacing HP1-alpha and HP1-gamma proteins in interphase, which leads to relocalization of the centromere chromatin proteins Mis12, Sgo1, and INCENP/CPC after prophase PubMed
vpr AurB and INCENP proteins targeting the inner centromere are reduced significantly in HIV-1 Vpr-expressing prometaphase cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora B signaling, organism-specific biosystem
    Aurora B signaling
  • Aurora C signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora C signaling, organism-specific biosystem
    Aurora C signaling
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    PLK1 signaling events, organism-specific biosystem
    PLK1 signaling events
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
    SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
  • SUMOylation, organism-specific biosystem (from REACTOME)
    SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
  • SUMOylation of DNA replication proteins, organism-specific biosystem (from REACTOME)
    SUMOylation of DNA replication proteins, organism-specific biosystemThe sliding clamp protein PCNA, Aurora-A, Aurora-B, Borealin, and various topoisomerases can be SUMOylated (reviewed in Wan et al. 2012). SUMOylation of PCNA appears to reduce formation of double-str...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31633, MGC111393

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic sister chromatid segregation IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
central element IEA
Inferred from Electronic Annotation
more info
 
chromocenter IEA
Inferred from Electronic Annotation
more info
 
chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
lateral element IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
midbody IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inner centromere protein
Names
binds and activates aurora-B and -C in vivo and in vitro
chromosomal passenger protein
inner centromere protein INCENP
inner centromere protein antigens 135/155kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040694.2NP_001035784.1  inner centromere protein isoform 1

    See identical proteins and their annotated locations for NP_001035784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AP002793, AW839685, BC098576, BC111732, CV569756
    Consensus CDS
    CCDS44624.1
    UniProtKB/Swiss-Prot
    Q9NQS7
    Related
    ENSP00000378295.3, ENST00000394818.7
    Conserved Domains (2) summary
    pfam03941
    Location:831882
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:641
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
  2. NM_020238.2NP_064623.2  inner centromere protein isoform 2

    See identical proteins and their annotated locations for NP_064623.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AP002793, AW839685, BC032678, BC098576, BC111732, CV569756
    Consensus CDS
    CCDS31582.1
    UniProtKB/Swiss-Prot
    Q9NQS7
    Related
    ENSP00000278849.4, ENST00000278849.4
    Conserved Domains (3) summary
    pfam03941
    Location:827878
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:641
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    cl00583
    Location:520613
    PhaG_MnhG_YufB; Na+/H+ antiporter subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    62123973..62155474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544995.3XP_011543297.1  inner centromere protein isoform X1

    Conserved Domains (2) summary
    pfam03941
    Location:846897
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:641
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
  2. XM_006718533.3XP_006718596.1  inner centromere protein isoform X5

    Conserved Domains (2) summary
    pfam03941
    Location:835886
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:641
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
  3. XM_011544996.3XP_011543298.1  inner centromere protein isoform X2

    Conserved Domains (2) summary
    pfam03941
    Location:842893
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:641
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
  4. XM_011544998.3XP_011543300.1  inner centromere protein isoform X4

    Conserved Domains (3) summary
    pfam03941
    Location:838889
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:641
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    cl00583
    Location:520613
    PhaG_MnhG_YufB; Na+/H+ antiporter subunit
  5. XM_011544997.2XP_011543299.1  inner centromere protein isoform X3

    Conserved Domains (3) summary
    pfam03941
    Location:842893
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:641
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    cl00583
    Location:520613
    PhaG_MnhG_YufB; Na+/H+ antiporter subunit
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