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Stk19 serine/threonine kinase 19 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361800, updated on 5-Mar-2024

Summary

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Official Symbol
Stk19provided by RGD
Official Full Name
serine/threonine kinase 19provided by RGD
Primary source
RGD:1359601
See related
Ensembl:ENSRNOG00000048929 AllianceGenome:RGD:1359601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity and small GTPase binding activity. Predicted to be involved in positive regulation of Ras protein signal transduction and protein phosphorylation. Predicted to be located in nuclear speck. Orthologous to human STK19 (serine/threonine kinase 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 89.4), Lung (RPKM 37.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stk19 in Genome Data Viewer
Location:
20p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4000216..4009743)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3995590..4005117)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4317440..4517128, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene SKI2 subunit of superkiller complex Neighboring gene decapping exoribonuclease Neighboring gene complement C4A Neighboring gene cytochrome P450, family 21, subfamily a, polypeptide 1 Neighboring gene tenascin XA, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase. Gomez-Escobar N, et al. J Biol Chem, 1998 Nov 20. PMID 9812991
  2. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Yin C, et al. Cell, 2019 Feb 21. PMID 30712867
  3. Physical mapping of the major histocompatibility complex class II and class III regions of the rat. Walter L, et al. Immunogenetics, 2002 Jul. PMID 12136338
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inactive serine/threonine-protein kinase 19
Names
serine/threonine-protein kinase 19
NP_001013215.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013197.2 → NP_001013215.2  inactive serine/threonine-protein kinase 19

    Status: VALIDATED

    Source sequence(s)
    BC061571, CO398403
    UniProtKB/TrEMBL
    A0A8I5ZJ96, Q6P7Q3
    Related
    ENSRNOP00000076734.1, ENSRNOT00000072446.4
    Conserved Domains (1) summary
    pfam10494
    Location:28 → 251
    Stk19; Serine-threonine protein kinase 19

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    4000216..4009743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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