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Ltb lymphotoxin beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 361795, updated on 21-Jul-2018

Summary

Official Symbol
Ltbprovided by RGD
Official Full Name
lymphotoxin betaprovided by RGD
Primary source
RGD:1303162
See related
Ensembl:ENSRNOG00000058566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Spleen (RPKM 278.5), Thymus (RPKM 258.4) and 5 other tissues See more
Orthologs

Genomic context

See Ltb in Genome Data Viewer
Location:
20p12
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5184631..5186476)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (6941753..6943598, complement)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene allograft inflammatory factor 1 Neighboring gene natural cytotoxicity triggering receptor 3 Neighboring gene leukocyte specific transcript 1 Neighboring gene lymphotoxin-alpha-like Neighboring gene tumor necrosis factor

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC108924

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor binding TAS
Traceable Author Statement
more info
PubMed 
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
immune response TAS
Traceable Author Statement
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
lymphotoxin-beta
Names
lymphotoxin B
lymphotoxin beta (TNF superfamily, member 3)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212507.2NP_997672.1  lymphotoxin-beta

    See identical proteins and their annotated locations for NP_997672.1

    Status: VALIDATED

    Source sequence(s)
    BC088208
    UniProtKB/TrEMBL
    Q6MG45
    Related
    ENSRNOP00000072122.1, ENSRNOT00000089411.1
    Conserved Domains (1) summary
    cd00184
    Location:154303
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    5184631..5186476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    4396109..4397954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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