U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sufu SUFU negative regulator of hedgehog signaling [ Rattus norvegicus (Norway rat) ]

Gene ID: 361769, updated on 11-Jun-2025
Official Symbol
Sufuprovided by RGD
Official Full Name
SUFU negative regulator of hedgehog signalingprovided by RGD
Primary source
RGD:1559462
See related
Ensembl:ENSRNOG00000019807 AllianceGenome:RGD:1559462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable beta-catenin binding activity and protein kinase binding activity. Involved in positive regulation of cellular response to drug and spermatid development. Predicted to be located in cilium and nucleoplasm. Predicted to be part of GLI-SUFU complex. Predicted to be active in cytoplasm and nucleus. Used to study medulloblastoma. Biomarker of brain glioblastoma multiforme and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome 2. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling). [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in Testes (RPKM 39.7), Kidney (RPKM 27.7) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See Sufu in Genome Data Viewer
Location:
1q54
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255199108..255296983)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245257725..245355576)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266143766..266241742)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 13A Neighboring gene actin related protein 1A Neighboring gene uncharacterized LOC134484078 Neighboring gene uncharacterized LOC134484077 Neighboring gene tripartite motif-containing 8 Neighboring gene ARF like GTPase 3 Neighboring gene transfer RNA histidine (anticodon AUG) 3

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within aorta development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within aorta development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within coronary vasculature development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within coronary vasculature development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dorsal/ventral neural tube patterning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart looping IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within heart looping ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within maintenance of protein localization in organelle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube closure IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skin development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skin development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_negative_effect smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within smoothened signaling pathway involved in ventral spinal cord interneuron specification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within smoothened signaling pathway involved in ventral spinal cord interneuron specification ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatid development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within spinal cord dorsal/ventral patterning IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spinal cord dorsal/ventral patterning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spinal cord motor neuron cell fate specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventral spinal cord interneuron specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular septum development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ventricular septum development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of GLI-SUFU complex IEA
Inferred from Electronic Annotation
more info
 
part_of GLI-SUFU complex ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
suppressor of fused homolog

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024899.2NP_001020070.1  suppressor of fused homolog isoform 1

    See identical proteins and their annotated locations for NP_001020070.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6A606, Q4V8C6
    Related
    ENSRNOP00000026987.5, ENSRNOT00000026987.7
    Conserved Domains (2) summary
    pfam05076
    Location:68240
    SUFU; Suppressor of fused protein (SUFU)
    pfam12470
    Location:254474
    SUFU_C; Suppressor of Fused Gli/Ci N terminal binding domain
  2. NM_001439944.1NP_001426873.1  suppressor of fused homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    255199108..255296983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231546.5XP_006231608.1  suppressor of fused homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6A606
    Related
    ENSRNOP00000087532.2, ENSRNOT00000095114.2
    Conserved Domains (2) summary
    pfam05076
    Location:68240
    SUFU; Suppressor of fused protein (SUFU)
    pfam12470
    Location:253473
    SUFU_C; Suppressor of Fused Gli/Ci N terminal binding domain