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Il33 interleukin 33 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361749, updated on 8-Dec-2022

Summary

Official Symbol
Il33provided by RGD
Official Full Name
interleukin 33provided by RGD
Primary source
RGD:1311155
See related
Ensembl:ENSRNOG00000016456 AllianceGenome:RGD:1311155
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311155
Summary
Predicted to enable cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of oligodendrocyte differentiation; and regulation of sensory perception of pain. Located in nucleus. Biomarker of acute myocardial infarction; colon cancer; and diabetes mellitus. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 677.6), Kidney (RPKM 455.7) and 8 other tissues See more
Orthologs
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Genomic context

See Il33 in Genome Data Viewer
Location:
1q52
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (227701964..227736374)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (248112611..248147030)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene RAN binding protein 6 Neighboring gene tRNA methyltransferase 6, pseudogene 1 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC120100019 Neighboring gene TPD52 like 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-33 receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-33 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-33-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-33-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microglial cell activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in microglial cell activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in microglial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T-helper 1 type immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T-helper 1 type immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of immunoglobulin production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of macrophage proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type II interferon production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of CD80 production IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of CD80 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of CD86 production IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of CD86 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MHC class I biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of MHC class I biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MHC class II biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular defense response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cellular defense response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immunoglobulin production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-13 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-13 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-4 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-5 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type 2 immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of type 2 immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type 2 immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in type 2 immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of type 2 immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014166.1NP_001014188.1  interleukin-33

    See identical proteins and their annotated locations for NP_001014188.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081993
    UniProtKB/Swiss-Prot
    Q66H70
    Related
    ENSRNOP00000022056.7, ENSRNOT00000022056.8
    Conserved Domains (1) summary
    pfam15095
    Location:5262
    IL33; Interleukin 33

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    227701964..227736374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084456.1XP_038940384.1  interleukin-33 isoform X1

    Conserved Domains (1) summary
    pfam15095
    Location:5292
    IL33; Interleukin 33
  2. XM_039084484.1XP_038940412.1  interleukin-33 isoform X2

    UniProtKB/Swiss-Prot
    Q66H70
    Conserved Domains (1) summary
    pfam15095
    Location:5262
    IL33; Interleukin 33
  3. XM_039084466.1XP_038940394.1  interleukin-33 isoform X1

    Conserved Domains (1) summary
    pfam15095
    Location:5292
    IL33; Interleukin 33
  4. XM_039084481.1XP_038940409.1  interleukin-33 isoform X1

    Conserved Domains (1) summary
    pfam15095
    Location:5292
    IL33; Interleukin 33
  5. XM_039084473.1XP_038940401.1  interleukin-33 isoform X1

    Conserved Domains (1) summary
    pfam15095
    Location:5292
    IL33; Interleukin 33
  6. XM_039084461.1XP_038940389.1  interleukin-33 isoform X1

    Conserved Domains (1) summary
    pfam15095
    Location:5292
    IL33; Interleukin 33
  7. XM_039084491.1XP_038940419.1  interleukin-33 isoform X2

    UniProtKB/Swiss-Prot
    Q66H70
    Conserved Domains (1) summary
    pfam15095
    Location:5262
    IL33; Interleukin 33