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Cyb561a3 cytochrome b561 family, member A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361729, updated on 30-May-2026
Official Symbol
Cyb561a3provided by RGD
Official Full Name
cytochrome b561 family, member A3provided by RGD
Primary source
RGD:1304670
See related
Ensembl:ENSRNOG00000020702 AllianceGenome:RGD:1304670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cybasc3; RGD1304670
Summary
Predicted to enable transmembrane ascorbate ferrireductase activity. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be located in late endosome membrane; lysosome; and nucleolus. Predicted to be active in lysosomal membrane. Orthologous to human CYB561A3 (cytochrome b561 family member A3). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Spleen (RPKM 445.5), Thymus (RPKM 73.2) and 7 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Cyb561a3 in Genome Data Viewer
Location:
1q43
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216641108..216662495)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207216185..207237575)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226620933..226642246)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene ribosomal protein L31, pseudogene 6 Neighboring gene transmembrane protein 138 Neighboring gene triokinase and FMN cyclase Neighboring gene damage-specific DNA binding protein 1 Neighboring gene von Willebrand factor C and EGF domains Neighboring gene pepsinogen F

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. An ascorbate-reducible cytochrome b561 is localized in macrophage lysosomes. Zhang DL, et al. Biochim Biophys Acta, 2006 Dec. PMID 16996694
  2. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane ascorbate ferrireductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane ascorbate ferrireductase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane ascorbate ferrireductase activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane ascorbate ferrireductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ascorbate homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular iron ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
lysosomal membrane ascorbate-dependent ferrireductase CYB561A3
Names
LCytb
cytochrome b ascorbate-dependent protein 3
cytochrome b, ascorbate dependent 3
lysosomal cytochrome b
NP_001014186.1
XP_006231111.1
XP_006231112.2
XP_006231113.2
XP_006231115.2
XP_006231116.2
XP_006231117.2
XP_038940141.1
XP_063124496.1
XP_063124498.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014164.2 → NP_001014186.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 19

    See identical proteins and their annotated locations for NP_001014186.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q5U2W7
    UniProtKB/TrEMBL
    A6I044
    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  2. NM_001443777.1 → NP_001430706.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I044

  3. NM_001443778.1 → NP_001430707.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I044

  4. NM_001443779.1 → NP_001430708.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZL22, A6I044

  5. NM_001443780.1 → NP_001430709.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZL22, A6I044

  6. NM_001443781.1 → NP_001430710.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZL22, A6I044

  7. NM_001443782.1 → NP_001430711.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZL22, A6I044

  8. NM_001443783.1 → NP_001430712.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZL22, A6I044

  9. NM_001443784.1 → NP_001430713.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZL22, A6I044

  10. NM_001443785.1 → NP_001430714.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8L2QF34, A6I044

  11. NM_001443786.1 → NP_001430715.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8L2QF34, A6I044

  12. NM_001443787.1 → NP_001430716.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8L2QF34, A6I044

  13. NM_001443788.1 → NP_001430717.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8L2QF34, A6I044

  14. NM_001443789.1 → NP_001430718.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8L2QF34, A6I044

  15. NM_001443790.1 → NP_001430719.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8L2QF34, A6I044

  16. NM_001443791.1 → NP_001430720.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8L2QF34, A6I044

  17. NM_001443792.1 → NP_001430721.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8L2QF34, A6I044

  18. NM_001443793.1 → NP_001430722.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RNA

  1. NR_201108.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    216641108..216662495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231049.5 → XP_006231111.1  

    Conserved Domains (1) summary
    cl23723
    Location:39 → 217
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  2. XM_039084213.2 → XP_038940141.1  

    Conserved Domains (1) summary
    cl23723
    Location:39 → 217
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  3. XM_006231050.5 → XP_006231112.2  

    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  4. XM_006231051.5 → XP_006231113.2  

    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  5. XM_006231053.5 → XP_006231115.2  

    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  6. XM_006231054.5 → XP_006231116.2  

    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  7. XM_063268426.1 → XP_063124496.1  

  8. XM_006231055.5 → XP_006231117.2  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZL22, A6I044
    Related
    ENSRNOP00000078502.1, ENSRNOT00000113027.2
    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  9. XM_063268428.1 → XP_063124498.1  

    Related
    ENSRNOP00000028094.6, ENSRNOT00000028094.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2W7.1 GenPept UniProtKB/Swiss-Prot:Q5U2W7

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