Tollip toll interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tollipprovided by RGD
Official Full Name: toll interacting proteinprovided by RGD
Primary source: RGD:1304676
See related: Ensembl:ENSRNOG00000019861 AllianceGenome:RGD:1304676
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables SUMO binding activity; enzyme binding activity; and interleukin-1, type I receptor binding activity. Involved in positive regulation of protein sumoylation. Located in nuclear body and perinuclear region of cytoplasm. Orthologous to human TOLLIP (toll interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Brain (RPKM 185.8), Kidney (RPKM 157.3) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 1q41

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (206391120..206413809, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (196961585..196984252, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we have identified miR291b as a critical miRNA up-regulated by ethanol. Normalization of the miR291b --> Tollip pathway by HA35 ameliorated ethanol-induced sensitization of TLR4 signaling in macrophages/monocytes, suggesting that HA35 may be a novel therapeutic agent in the treatment of Alcoholic liver disease.
Title: Hyaluronic acid 35 normalizes TLR4 signaling in Kupffer cells from ethanol-fed rats via regulation of microRNA291b and its target Tollip.
This study demonstrated B. adolescentis prevents NEC in preterm neonatal rats and that the mechanism for this action might be associated with the alteration of TLR4, TOLLIP, and SIGIRR expression.
Title: Bifidobacterium adolescentis protects against necrotizing enterocolitis and upregulates TOLLIP and SIGIRR in premature neonatal rats.
Tollip acts as a novel modulator of I/R injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of Akt signalling.
Title: Tollip is a critical mediator of cerebral ischaemia-reperfusion injury.
Daata indicate that Xuebijing (XBJ) significantly reduced ligation and puncture (CLP)-induced lung permeability by upregulating Toll-interacting protein (Tollip) expression.
Title: Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis.
The disbalance between TLRs and their negative regulating factors PPAR-gamma and Tollip was closely associated with the course of colitis.
Title: PPAR-γ and tollip are associated with toll-like receptors in colitis rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133412 (e-PCR)
- UniSTS:216695

BE112982 (e-PCR)
- UniSTS:246253

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SUMO binding	IPI Inferred from Physical Interaction more info	PubMed
enables Toll-like receptor binding	IEA Inferred from Electronic Annotation more info
enables Toll-like receptor binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1, type I receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in interleukin-1-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to endosome	IEA Inferred from Electronic Annotation more info
involved_in protein localization to endosome	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: toll-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109668.1 → NP_001103138.1 toll-interacting protein

See identical proteins and their annotated locations for NP_001103138.1

Status: PROVISIONAL

Source sequence(s)

CH473953

UniProtKB/Swiss-Prot

A2RUW1

Related

ENSRNOP00000049498.2, ENSRNOT00000046344.5

Conserved Domains (2) summary

cd04016
Location:52 → 172

C2_Tollip; C2 domain present in Toll-interacting protein (Tollip)

cd14363
Location:230 → 270

CUE_TOLIP; CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

206391120..206413809 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083487.2 → XP_038939415.1 toll-interacting protein isoform X2

Conserved Domains (2) summary

cd04016
Location:1 → 103

C2_Tollip; C2 domain present in Toll-interacting protein (Tollip)

cd14363
Location:161 → 201

CUE_TOLIP; CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins
XM_039083484.2 → XP_038939412.1 toll-interacting protein isoform X1

UniProtKB/TrEMBL

A0A8I6A889

Related

ENSRNOP00000087930.1, ENSRNOT00000103130.2

Conserved Domains (2) summary

cd04016
Location:48 → 168

C2_Tollip; C2 domain present in Toll-interacting protein (Tollip)

cd14363
Location:226 → 266

CUE_TOLIP; CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins