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Lhpp phospholysine phosphohistidine inorganic pyrophosphate phosphatase [ Rattus norvegicus (Norway rat) ]

Gene ID: 361663, updated on 8-Apr-2026
Official Symbol
Lhppprovided by RGD
Official Full Name
phospholysine phosphohistidine inorganic pyrophosphate phosphataseprovided by RGD
Primary source
RGD:1359187
See related
Ensembl:ENSRNOG00000017097 AllianceGenome:RGD:1359187
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable inorganic diphosphate phosphatase activity; phosphatase activity; and protein homodimerization activity. Predicted to be involved in phosphate-containing compound metabolic process. Predicted to be located in nuclear speck. Predicted to be active in cytosol. Orthologous to human LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Kidney (RPKM 80.3), Liver (RPKM 61.9) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Lhpp in Genome Data Viewer
Location:
1q41
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (196833516..196924687)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (187403390..187494577)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (204617804..204708987)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ornithine aminotransferase Neighboring gene NK1 homeobox 2 Neighboring gene uncharacterized LOC120099944 Neighboring gene uncharacterized LOC120099945 Neighboring gene family with sequence similarity 53, member B Neighboring gene uncharacterized LOC134483949 Neighboring gene EEF1A lysine methyltransferase 2 Neighboring gene uncharacterized LOC102552031

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Expression of new human inorganic pyrophosphatase in thyroid diseases: its intimate association with hyperthyroidism. Koike E, et al. Biochem Biophys Res Commun, 2006 Mar 17. PMID 16430861
  2. Molecular cloning of a cDNA for the human phospholysine phosphohistidine inorganic pyrophosphate phosphatase. Yokoi F, et al. J Biochem, 2003 May. PMID 12801912
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC95092

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables inorganic diphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inorganic diphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inorganic diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inorganic diphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phosphate-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphate-containing compound metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
NP_001009706.1
XP_063123970.1
XP_063123973.1
XP_063123974.1
XP_063123975.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009706.1 → NP_001009706.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase

    See identical proteins and their annotated locations for NP_001009706.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088448
    UniProtKB/Swiss-Prot
    Q5I0D5
    UniProtKB/TrEMBL
    A0A8I6GMN4
    Related
    ENSRNOP00000022971.5, ENSRNOT00000022971.5
    Conserved Domains (3) summary
    TIGR01458
    Location:11 → 267
    HAD-SF-IIA-hyp3; HAD-superfamily subfamily IIA hydrolase, TIGR01458
    pfam13242
    Location:186 → 260
    Hydrolase_like; HAD-hyrolase-like
    pfam13344
    Location:14 → 112
    Hydrolase_6; Haloacid dehalogenase-like hydrolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    196833516..196924687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267904.1 → XP_063123974.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X3

    UniProtKB/TrEMBL
    A0ABK0L964

  2. XM_063267900.1 → XP_063123970.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X1

    UniProtKB/TrEMBL
    A0ABK0L393, A0ABK0LZY7
    Related
    ENSRNOP00000103549.1, ENSRNOT00000130163.1

  3. XM_063267903.1 → XP_063123973.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X2

    UniProtKB/TrEMBL
    A0ABK0L964
    Related
    ENSRNOP00000107655.1, ENSRNOT00000127562.1

  4. XM_063267905.1 → XP_063123975.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I0D5.1 GenPept UniProtKB/Swiss-Prot:Q5I0D5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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