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Plekha1 pleckstrin homology domain containing A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361659, updated on 12-Aug-2018

Summary

Official Symbol
Plekha1provided by RGD
Official Full Name
pleckstrin homology domain containing A1provided by RGD
Primary source
RGD:1564153
See related
Ensembl:ENSRNOG00000020497
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564153
Expression
Biased expression in Lung (RPKM 273.5), Brain (RPKM 211.3) and 9 other tissues See more
Orthologs

Genomic context

See Plekha1 in Genome Data Viewer
Location:
1q41
Exon count:
15
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (201429716..201481411)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (208462186..208513824)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene transforming, acidic coiled-coil containing protein 2 Neighboring gene uncharacterized LOC103691241 Neighboring gene BTB domain containing 16 Neighboring gene HtrA serine peptidase 1 Neighboring gene deleted in malignant brain tumors 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC156706

Gene Ontology Provided by RGD

Function Evidence Code Pubs
PDZ domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
phosphatidylinositol-3,4-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Leydig cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Leydig cell differentiation ISO
Inferred from Sequence Orthology
more info
 
androgen metabolic process IEA
Inferred from Electronic Annotation
more info
 
androgen metabolic process ISO
Inferred from Sequence Orthology
more info
 
biological_process ND
No biological Data available
more info
 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
estrogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
estrogen metabolic process ISO
Inferred from Sequence Orthology
more info
 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
face morphogenesis ISO
Inferred from Sequence Orthology
more info
 
female gonad development ISO
Inferred from Sequence Orthology
more info
 
luteinization IEA
Inferred from Electronic Annotation
more info
 
luteinization ISO
Inferred from Sequence Orthology
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
roof of mouth development ISO
Inferred from Sequence Orthology
more info
 
ruffle organization IEA
Inferred from Electronic Annotation
more info
 
ruffle organization ISO
Inferred from Sequence Orthology
more info
 
skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
ruffle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pleckstrin homology domain-containing family A member 1
Names
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
pleckstrin homology domain-containing protein family A member 1
tandem PH domain containing protein-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079894.1NP_001073363.1  pleckstrin homology domain-containing family A member 1

    See identical proteins and their annotated locations for NP_001073363.1

    Status: PROVISIONAL

    Source sequence(s)
    BC128752
    UniProtKB/TrEMBL
    A1A5P7
    Related
    ENSRNOP00000027836.3, ENSRNOT00000027836.4
    Conserved Domains (3) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:192288
    PH; PH domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    201429716..201481411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230412.3XP_006230474.1  pleckstrin homology domain-containing family A member 1 isoform X3

    Conserved Domains (3) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:202298
    PH; PH domain
  2. XM_006230415.3XP_006230477.1  pleckstrin homology domain-containing family A member 1 isoform X5

    Conserved Domains (3) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:202298
    PH; PH domain
  3. XM_017589426.1XP_017444915.1  pleckstrin homology domain-containing family A member 1 isoform X1

    Conserved Domains (3) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:202298
    PH; PH domain
  4. XM_006230413.3XP_006230475.1  pleckstrin homology domain-containing family A member 1 isoform X4

    Related
    ENSRNOP00000071765.1, ENSRNOT00000078244.1
    Conserved Domains (3) summary
    cd13271
    Location:195306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:202298
    PH; PH domain
    cl17171
    Location:1117
    PH-like; Pleckstrin homology-like domain
  5. XM_006230409.3XP_006230471.1  pleckstrin homology domain-containing family A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006230471.1

    Conserved Domains (3) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:202298
    PH; PH domain
  6. XM_008759909.2XP_008758131.1  pleckstrin homology domain-containing family A member 1 isoform X2

    See identical proteins and their annotated locations for XP_008758131.1

    Conserved Domains (3) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:192288
    PH; PH domain
  7. XM_017589427.1XP_017444916.1  pleckstrin homology domain-containing family A member 1 isoform X6

    UniProtKB/TrEMBL
    A1A5P7
    Conserved Domains (3) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:192288
    PH; PH domain
  8. XM_008759908.2XP_008758130.1  pleckstrin homology domain-containing family A member 1 isoform X1

    See identical proteins and their annotated locations for XP_008758130.1

    Conserved Domains (3) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:202298
    PH; PH domain
  9. XM_008759910.1XP_008758132.1  pleckstrin homology domain-containing family A member 1 isoform X7

    Conserved Domains (3) summary
    cd13271
    Location:113224
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:120216
    PH; PH domain
    cl17171
    Location:135
    PH-like; Pleckstrin homology-like domain

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    183040481..183091589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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