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Acsm1 acyl-CoA synthetase medium-chain family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361638, updated on 10-Feb-2026
Official Symbol
Acsm1provided by RGD
Official Full Name
acyl-CoA synthetase medium-chain family member 1provided by RGD
Primary source
RGD:1306813
See related
Ensembl:ENSRNOG00000042084 AllianceGenome:RGD:1306813
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bucs1
Summary
Predicted to enable benzoate-CoA ligase activity; decanoate-CoA ligase activity; and long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in mitochondrial matrix. Orthologous to human ACSM1 (acyl-CoA synthetase medium chain family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Restricted expression toward (RPKM 743.0) See more
Orthologs
all
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Try the new Transcripts and proteins table
See Acsm1 in Genome Data Viewer
Location:
1q35
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (183417052..183451897)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (173985715..174020565)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (189359374..189395277)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase-like, testis expressed Neighboring gene acyl-CoA synthetase medium-chain family member 5 Neighboring gene acyl-CoA synthetase medium-chain family member 2 Neighboring gene RGD1559600 Neighboring gene acyl-CoA synthetase medium-chain family member 4 Neighboring gene uncharacterized LOC134483776 Neighboring gene THUMP domain 1 NAT10 acetyltransferase adaptor

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. O-MACS, a novel member of the medium-chain acyl-CoA synthetase family, specifically expressed in the olfactory epithelium in a zone-specific manner. Oka Y, et al. Eur J Biochem, 2003 May. PMID 12709059
  2. Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids. Vessey DA, et al. Biochim Biophys Acta, 1999 Aug 5. PMID 10434065
  3. Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. Fujino T, et al. J Biol Chem, 2001 Sep 21. PMID 11470804
  4. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Preferred Names
acyl-coenzyme A synthetase ACSM1, mitochondrial
Names
butyryl Coenzyme A synthetase 1
NP_001101972.2
XP_063123671.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108502.2 → NP_001101972.2  acyl-coenzyme A synthetase ACSM1, mitochondrial

    See identical proteins and their annotated locations for NP_001101972.2

    Status: PROVISIONAL

    Source sequence(s)
    BC168985
    UniProtKB/TrEMBL
    B5DFA3, F1M1W1
    Related
    ENSRNOP00000099262.1, ENSRNOT00000129689.1
    Conserved Domains (2) summary
    COG0365
    Location:46 → 570
    Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]
    cl17068
    Location:46 → 573
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    183417052..183451897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267601.1 → XP_063123671.1  acyl-coenzyme A synthetase ACSM1, mitochondrial isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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