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alka alkaliphile [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36145, updated on 4-Jul-2024

Summary

Official Symbol
alkaprovided by FlyBase
Official Full Name
alkaliphileprovided by FlyBase
Primary source
FLYBASE:FBgn0033558
Locus tag
Dmel_CG12344
See related
AllianceGenome:FB:FBgn0033558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12344; CT23391; Dmel\CG12344; Lcch-47C
Summary
Predicted to enable neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Involved in glycinergic synaptic transmission; negative regulation of neuronal action potential; and regulation of circadian rhythm. Predicted to be active in neuron projection and synapse. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hyperekplexia 1 and hyperekplexia 2. Orthologous to several human genes including GLRA1 (glycine receptor alpha 1); GLRA2 (glycine receptor alpha 2); and GLRA3 (glycine receptor alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See alka in Genome Data Viewer
Location:
47C1-47C2; 2-63 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10827430..10835709, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6714935..6723214, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S15Ab Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene LTV1 ribosome biogenesis factor Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45136

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables glycine-gated chloride ion channel activity TAS
Traceable Author Statement
more info
PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
alkaliphile
Names
CG12344-PA
CG12344-PB
CG12344-PC
CG12344-PD
alka-PA
alka-PB
alka-PC
alka-PD
glycine receptor alpha2-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10827430..10835709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299370.1NP_001286299.1  alkaliphile, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286299.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LF41
    Conserved Domains (1) summary
    TIGR00860
    Location:8437
    LIC; Cation transporter family protein
  2. NM_001299369.1NP_001286298.1  alkaliphile, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286298.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SWZ1, Q9V5Q6
    Conserved Domains (1) summary
    TIGR00860
    Location:8441
    LIC; Cation transporter family protein
  3. NM_001299368.1NP_001286297.1  alkaliphile, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286297.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LF41
    Conserved Domains (1) summary
    TIGR00860
    Location:8437
    LIC; Cation transporter family protein
  4. NM_136775.3NP_610619.2  alkaliphile, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610619.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SWZ1, Q9V5Q6
    Related
    FBpp0087341
    Conserved Domains (1) summary
    TIGR00860
    Location:8441
    LIC; Cation transporter family protein