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Sipa1l2 signal-induced proliferation-associated 1 like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361442, updated on 13-Aug-2019

Summary

Official Symbol
Sipa1l2provided by RGD
Official Full Name
signal-induced proliferation-associated 1 like 2provided by RGD
Primary source
RGD:1306269
See related
Ensembl:ENSRNOG00000019791
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Spar2; Sersap2
Expression
Biased expression in Heart (RPKM 139.7), Lung (RPKM 120.8) and 9 other tissues See more
Orthologs

Genomic context

See Sipa1l2 in Genome Data Viewer
Location:
19q12
Exon count:
24
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (58236201..58399842, complement)
106 current Rn_Celera (GCF_000002265.2) 19 AC_000087.1 (52750929..52853027, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (68936975..69098880, complement)

Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene DISC1 scaffold protein Neighboring gene spore coat protein SP65-like Neighboring gene uncharacterized LOC102557452 Neighboring gene SET nuclear proto-oncogene Neighboring gene microtubule-associated protein 10

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
signal-induced proliferation-associated 1-like protein 2
Names
SIPA1-like protein 2
serine-rich synapse associated protein 2
serine-rich synapse-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009704.1NP_001009704.1  signal-induced proliferation-associated 1-like protein 2

    See identical proteins and their annotated locations for NP_001009704.1

    Status: PROVISIONAL

    Source sequence(s)
    AY043227
    UniProtKB/Swiss-Prot
    Q5JCS6
    Related
    ENSRNOP00000026843.7, ENSRNOT00000026843.7
    Conserved Domains (3) summary
    cd00992
    Location:9511021
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:626806
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14231666
    SPAR_C; C-terminal domain of SPAR protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

    Range
    58236201..58399842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772639.1XP_008770861.1  signal-induced proliferation-associated 1-like protein 2 isoform X3

    Conserved Domains (3) summary
    cd00992
    Location:9511021
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:626806
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14231604
    SPAR_C; C-terminal domain of SPAR protein
  2. XM_008772638.1XP_008770860.1  signal-induced proliferation-associated 1-like protein 2 isoform X2

    Conserved Domains (3) summary
    cd00992
    Location:9511021
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:626806
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14231648
    SPAR_C; C-terminal domain of SPAR protein
  3. XM_017601330.1XP_017456819.1  signal-induced proliferation-associated 1-like protein 2 isoform X1

    UniProtKB/TrEMBL
    F1M8G8

Alternate Rn_Celera

Genomic

  1. AC_000087.1 Alternate Rn_Celera

    Range
    52750929..52853027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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