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Cdh15 cadherin 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361432, updated on 24-Apr-2022

Summary

Official Symbol
Cdh15provided by RGD
Official Full Name
cadherin 15provided by RGD
Primary source
RGD:1303000
See related
Ensembl:ENSRNOG00000027954 AllianceGenome:RGD:1303000
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cadherin binding activity and calcium ion binding activity. Predicted to be involved in cell-cell adhesion via plasma-membrane adhesion molecules. Predicted to be located in Golgi apparatus; caveola; and neuromuscular junction. Predicted to be part of catenin complex. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 3. Orthologous to human CDH15 (cadherin 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 66.4), Brain (RPKM 45.9) and 1 other tissue See more
Orthologs
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Genomic context

See Cdh15 in Genome Data Viewer
Location:
19q12
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50903757..50927151)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55669661..55689986)

Chromosome 19 - NC_051354.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909629 Neighboring gene uncharacterized LOC120098494 Neighboring gene uncharacterized LOC108348960 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene acyl-CoA synthetase family member 3 Neighboring gene ankyrin repeat domain containing 11 Neighboring gene small nucleolar RNA U3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cadherin-15
Names
M-cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207613.1NP_997496.1  cadherin-15 precursor

    See identical proteins and their annotated locations for NP_997496.1

    Status: PROVISIONAL

    Source sequence(s)
    AB176538
    UniProtKB/TrEMBL
    Q75NI5
    Conserved Domains (3) summary
    cd11304
    Location:155255
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam00028
    Location:270366
    Cadherin; Cadherin domain
    pfam01049
    Location:639782
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051354.1 Reference mRatBN7.2 Primary Assembly

    Range
    50903757..50927151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097879.1XP_038953807.1  cadherin-15 isoform X1

    Related
    ENSRNOP00000094457.1, ENSRNOT00000109297.1