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Dnaaf1 dynein, axonemal, assembly factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361419, updated on 6-Jul-2026
Official Symbol
Dnaaf1provided by RGD
Official Full Name
dynein, axonemal, assembly factor 1provided by RGD
Primary source
RGD:1310542
See related
Ensembl:ENSRNOG00000015590 AllianceGenome:RGD:1310542
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lrrc50; RGD1310542
Summary
Predicted to enable dynein complex binding activity. Predicted to be involved in several processes, including cilium assembly; determination of left/right symmetry; and regulation of cilium beat frequency. Predicted to be located in cilium. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 13. Orthologous to human DNAAF1 (dynein axonemal assembly factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Restricted expression toward (RPKM 813.5) See more
Orthologs
all
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Try the new Transcripts and proteins table
See Dnaaf1 in Genome Data Viewer
Location:
19q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (64532859..64560942)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (47624534..47652314)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene N-terminal EF-hand calcium binding protein 2 Neighboring gene solute carrier family 38, member 8 Neighboring gene membrane-bound transcription factor peptidase, site 1 Neighboring gene hydroxysteroid dehydrogenase like 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2, pseudogene 3 Neighboring gene TATA-box binding protein associated factor, RNA polymerase 1 subunit C Neighboring gene adenosine deaminase domain containing 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Loss-of-function mutations in the human ortholog of Chlamydomonas reinhardtii ODA7 disrupt dynein arm assembly and cause primary ciliary dyskinesia. Duquesnoy P, et al. Am J Hum Genet, 2009 Dec. PMID 19944405, Free PMC Article
  2. Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects. Loges NT, et al. Am J Hum Genet, 2009 Dec. PMID 19944400, Free PMC Article
  3. LRRC50, a conserved ciliary protein implicated in polycystic kidney disease. van Rooijen E, et al. J Am Soc Nephrol, 2008 Jun. PMID 18385425, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in axonemal dynein complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium movement ISO
Inferred from Sequence Orthology
more info
  
involved_in determination of digestive tract left/right asymmetry ISO
Inferred from Sequence Orthology
more info
  
involved_in determination of left/right symmetry IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in determination of liver left/right asymmetry ISO
Inferred from Sequence Orthology
more info
  
involved_in determination of pancreatic left/right asymmetry ISO
Inferred from Sequence Orthology
more info
  
involved_in heart looping ISO
Inferred from Sequence Orthology
more info
  
involved_in inner dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in left/right pattern formation ISO
Inferred from Sequence Orthology
more info
  
involved_in lung development ISO
Inferred from Sequence Orthology
more info
  
involved_in motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cilium beat frequency ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
dynein axonemal assembly factor 1
Names
dynein assembly factor 1, axonemal
leucine rich repeat containing 50
leucine-rich repeat-containing protein 50

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014154.1 → NP_001014176.1  dynein axonemal assembly factor 1

    See identical proteins and their annotated locations for NP_001014176.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079038
    UniProtKB/Swiss-Prot
    Q6AYH9
    UniProtKB/TrEMBL
    A0A8I6A474
    Related
    ENSRNOP00000020917.3, ENSRNOT00000020917.6
    Conserved Domains (3) summary
    cd00116
    Location:116 → 252
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:105 → 124
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:145 → 201
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    64532859..64560942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601323.3 → XP_017456812.1  dynein axonemal assembly factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K5B1, A0A8I6A474
    Related
    ENSRNOP00000073360.1, ENSRNOT00000079580.3

  2. XM_063278144.1 → XP_063134214.1  dynein axonemal assembly factor 1 isoform X1

  3. XM_063278145.1 → XP_063134215.1  dynein axonemal assembly factor 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYH9.1 GenPept UniProtKB/Swiss-Prot:Q6AYH9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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