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Rfwd3 ring finger and WD repeat domain 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361409, updated on 9-Oct-2018

Summary

Official Symbol
Rfwd3provided by RGD
Official Full Name
ring finger and WD repeat domain 3provided by RGD
Primary source
RGD:1305243
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305243
Expression
Biased expression in Thymus (RPKM 71.7), Spleen (RPKM 66.5) and 9 other tissues See more

Genomic context

See Rfwd3 in Genome Data Viewer
Location:
19q12
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (42960597..42971894)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (53787638..53798031) , (54289116..54310716, complement)

Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene zinc finger homeobox 3 Neighboring gene uncharacterized LOC108348931 Neighboring gene uncharacterized LOC108353195 Neighboring gene golgi glycoprotein 1 Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

  • Homologs of the Rfwd3 gene: The Rfwd3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, and frog.

Gene Ontology Provided by RGD

Function Evidence Code Pubs
MDM2/MDM4 family protein binding ISO
Inferred from Sequence Orthology
more info
 
p53 binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
chromosome breakage ISO
Inferred from Sequence Orthology
more info
 
double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
 
mitotic G1 DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
replication fork processing ISO
Inferred from Sequence Orthology
more info
 
response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
site of DNA damage ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RFWD3-like

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

    Range
    42960597..42971894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255619.3XP_006255681.1  E3 ubiquitin-protein ligase RFWD3-like

    Conserved Domains (3) summary
    COG2319
    Location:47160
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:4071
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:40105
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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