Dok4 docking protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dok4provided by RGD
Official Full Name: docking protein 4provided by RGD
Primary source: RGD:1310084
See related: Ensembl:ENSRNOG00000015679 AllianceGenome:RGD:1310084
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within nervous system development and positive regulation of MAPK cascade. Predicted to be active in cytoplasm. Orthologous to human DOK4 (docking protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Kidney (RPKM 101.5), Lung (RPKM 86.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (10152511..10163182)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (10146520..10157187)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (10563423..10574094)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dok4 is a novel player in Schwann cell-axon interaction and is required at early stages of myelination; it also aids Schwann cell migration and proliferation.
Title: Dok4 is involved in Schwann cell myelination and axonal interaction in vitro.

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General gene information

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Markers

RH141364 (e-PCR)
- UniSTS:223360

RH130355 (e-PCR)
- UniSTS:213639

Dok4 (e-PCR), detects polymorphism
- UniSTS:502752

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: docking protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108438.2 → NP_001101908.1 docking protein 4

See identical proteins and their annotated locations for NP_001101908.1

Status: PROVISIONAL

Source sequence(s)

BC158749

UniProtKB/TrEMBL

B0BNA8, F7FET5

Related

ENSRNOP00000021037.6, ENSRNOT00000021037.7

Conserved Domains (3) summary

cd13164
Location:133 → 235

PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)

cd14678
Location:9 → 113

PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins

pfam00169
Location:8 → 108

PH; PH domain