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Fech ferrochelatase [ Rattus norvegicus (Norway rat) ]

Gene ID: 361338, updated on 21-Jul-2018

Summary

Official Symbol
Fechprovided by RGD
Official Full Name
ferrochelataseprovided by RGD
Primary source
RGD:1307556
See related
Ensembl:ENSRNOG00000018053
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Spleen (RPKM 360.4), Heart (RPKM 133.2) and 8 other tissues See more
Orthologs

Genomic context

See Fech in Genome Data Viewer
Location:
18q12.1
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (59941992..59975192, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (59152151..59185351, complement)

Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553013 Neighboring gene RGD1562699 Neighboring gene one cut homeobox 2 Neighboring gene asparaginyl-tRNA synthetase Neighboring gene ATPase phospholipid transporting 8B1 Neighboring gene uncharacterized LOC102553500

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ferrochelatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ferrochelatase activity IDA
Inferred from Direct Assay
more info
PubMed 
ferrochelatase activity ISO
Inferred from Sequence Orthology
more info
 
heme binding ISO
Inferred from Sequence Orthology
more info
 
iron ion binding ISO
Inferred from Sequence Orthology
more info
 
iron-responsive element binding ISO
Inferred from Sequence Orthology
more info
 
tetrapyrrole binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
detection of UV ISO
Inferred from Sequence Orthology
more info
 
erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
heme metabolic process TAS
Traceable Author Statement
more info
PubMed 
iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
porphyrin-containing compound biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
protoporphyrinogen IX metabolic process IEA
Inferred from Electronic Annotation
more info
 
protoporphyrinogen IX metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of eIF2 alpha phosphorylation by heme ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of hemoglobin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
response to arsenic-containing substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to insecticide IEP
Inferred from Expression Pattern
more info
PubMed 
response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to light stimulus ISO
Inferred from Sequence Orthology
more info
 
response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to methylmercury IEP
Inferred from Expression Pattern
more info
PubMed 
response to platinum ion IEP
Inferred from Expression Pattern
more info
PubMed 
very-low-density lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ferrochelatase, mitochondrial
NP_001101904.1
XP_006254912.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108434.1NP_001101904.1  ferrochelatase, mitochondrial

    See identical proteins and their annotated locations for NP_001101904.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473971
    UniProtKB/TrEMBL
    D3ZBM3
    Related
    ENSRNOP00000024328.4, ENSRNOT00000024328.4
    Conserved Domains (3) summary
    cd00419
    Location:234371
    Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    cd03411
    Location:68229
    Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    pfam00762
    Location:68388
    Ferrochelatase; Ferrochelatase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

    Range
    59941992..59975192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254850.3XP_006254912.1  ferrochelatase, mitochondrial isoform X1

    Conserved Domains (3) summary
    cd00419
    Location:265402
    Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    cd03411
    Location:99260
    Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    pfam00762
    Location:99419
    Ferrochelatase; Ferrochelatase

Alternate Rn_Celera

Genomic

  1. AC_000086.1 Alternate Rn_Celera

    Range
    56082277..56115455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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