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Fech ferrochelatase [ Rattus norvegicus (Norway rat) ]

Gene ID: 361338, updated on 25-Jan-2024

Summary

Official Symbol
Fechprovided by RGD
Official Full Name
ferrochelataseprovided by RGD
Primary source
RGD:1307556
See related
Ensembl:ENSRNOG00000018053 AllianceGenome:RGD:1307556
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables ferrochelatase activity. Involved in several processes, including cellular response to dexamethasone stimulus; response to lead ion; and response to platinum ion. Located in mitochondrion. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 360.4), Heart (RPKM 133.2) and 8 other tissues See more
Orthologs
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Genomic context

See Fech in Genome Data Viewer
Location:
18q12.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_06 current mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (57945123..57978327, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (59941992..59975192, complement)

Chromosome 18 - NC_051353.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553013 Neighboring gene RGD1562699 Neighboring gene one cut homeobox 2 Neighboring gene asparaginyl-tRNA synthetase 1 Neighboring gene ATPase phospholipid transporting 8B1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables ferrochelatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ferrochelatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ferrochelatase activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
 
enables iron-responsive element binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables tetrapyrrole binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within detection of UV ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in heme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme B biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme O biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heme biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme metabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protoporphyrinogen IX metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protoporphyrinogen IX metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of eIF2 alpha phosphorylation by heme ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of hemoglobin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to arsenic-containing substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insecticide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to light stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to methylmercury IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to platinum ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within very-low-density lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ferrochelatase, mitochondrial
NP_001101904.1
XP_006254912.1
XP_038952906.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108434.1NP_001101904.1  ferrochelatase, mitochondrial

    See identical proteins and their annotated locations for NP_001101904.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473971
    UniProtKB/TrEMBL
    A0A8I5ZR41, A6IXN8, D3ZBM3
    Related
    ENSRNOP00000024328.4, ENSRNOT00000024328.5
    Conserved Domains (3) summary
    cd00419
    Location:234371
    Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    cd03411
    Location:68229
    Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    pfam00762
    Location:68388
    Ferrochelatase; Ferrochelatase

RefSeqs of Annotated Genomes: GCF_015227675.2-RS_2023_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051353.1 Reference mRatBN7.2 Primary Assembly

    Range
    57945123..57978327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096978.1XP_038952906.1  ferrochelatase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZR41
    Conserved Domains (1) summary
    pfam00762
    Location:1317
    Ferrochelatase
  2. XM_006254850.4XP_006254912.1  ferrochelatase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I6GEM4
    Related
    ENSRNOP00000086143.1, ENSRNOT00000110759.1
    Conserved Domains (3) summary
    cd00419
    Location:265402
    Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    cd03411
    Location:99260
    Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    pfam00762
    Location:99419
    Ferrochelatase; Ferrochelatase