Cdnf cerebral dopamine neurotrophic factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdnfprovided by RGD
Official Full Name: cerebral dopamine neurotrophic factorprovided by RGD
Primary source: RGD:1307600
See related: EnsemblRapid:ENSRNOG00000026493 AllianceGenome:RGD:1307600
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Armetl1
Summary: Predicted to enable growth factor activity. Predicted to be involved in dopaminergic neuron differentiation and neuron projection development. Predicted to be active in endoplasmic reticulum and extracellular space. Orthologous to human CDNF (cerebral dopamine neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Heart (RPKM 217.7), Muscle (RPKM 215.1) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (79623728..79637800, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (74714564..74728639, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (78721230..78735324, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cerebral dopamine neurotrophic factor (CDNF) protects against quinolinic acid-induced toxicity in in vitro and in vivo models of Huntington's disease.
Title: Cerebral dopamine neurotrophic factor (CDNF) protects against quinolinic acid-induced toxicity in in vitro and in vivo models of Huntington's disease.
Results demonstrated that CDNF overexpression in the brain could attenuate the METH-induced dopamine and tyrosine hydroxylase loss in the striatum but could not lower METH-induced hyperthermia.
Title: Recombinant AAV8-mediated intrastriatal gene delivery of CDNF protects rats against methamphetamine neurotoxicity.
In all, these findings suggest that helix-7 in the C-terminal is important for CDNF secretion, which maybe potential affect CDNF function in ER stress.
Title: Key subdomains in the C-terminal of cerebral dopamine neurotrophic factor regulate the protein secretion.
Data show that overexpression of conserved dopamine neurotrophic factor (CDNF) in astrocytes alleviated cell damage and proinflammatory cytokine secretion, which may represent a promising strategy for neuroprotection in the central nervous system (CNS).
Title: Overexpression of conserved dopamine neurotrophic factor (CDNF) in astrocytes alleviates endoplasmic reticulum stress-induced cell damage and inflammatory cytokine secretion.
Disruption of the helix-1 domain of cerebral dopamine neurotrophic factor significantly reduces its secretion in endoplasmic reticulum.
Title: Intracellular trafficking and secretion of cerebral dopamine neurotrophic factor in neurosecretory cells.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dopaminergic neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cerebral dopamine neurotrophic factor

Names: ARMET-like protein 1; arginine-rich protein mutated in early stage tumors-like 1; arginine-rich, mutated in early stage tumors-like 1; conserved dopamine neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.