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Bag4 BAG cochaperone 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361167, updated on 5-Jan-2022

Summary

Official Symbol
Bag4provided by RGD
Official Full Name
BAG cochaperone 4provided by RGD
Primary source
RGD:1560875
See related
Ensembl:ENSRNOG00000042560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase binding activity. Involved in negative regulation of mRNA modification. Located in cytoplasm and nucleus. Orthologous to human BAG4 (BAG cochaperone 4). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Brain (RPKM 103.6), Kidney (RPKM 86.2) and 9 other tissues See more
Orthologs
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Genomic context

See Bag4 in Genome Data Viewer
Location:
16q12.4
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66288678..66305893)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71057709..71075874)

Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097390 Neighboring gene ASH2 like histone lysine methyltransferase complex subunit Neighboring gene steroidogenic acute regulatory protein Neighboring gene LSM1 homolog, mRNA degradation associated Neighboring gene translation initiation factor IF-2-like Neighboring gene U6 spliceosomal RNA Neighboring gene DDHD domain containing 2 Neighboring gene phospholipid phosphatase 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
BAG family molecular chaperone regulator 4
Names
BCL2-associated athanogene 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025130.1NP_001020301.1  BAG family molecular chaperone regulator 4

    See identical proteins and their annotated locations for NP_001020301.1

    Status: VALIDATED

    Source sequence(s)
    BC083608
    UniProtKB/TrEMBL
    Q5XIR5
    Related
    ENSRNOP00000061900.4, ENSRNOT00000066901.4
    Conserved Domains (1) summary
    smart00264
    Location:379456
    BAG; BAG domains, present in regulator of Hsp70 proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

    Range
    66288678..66305893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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