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Eps15l1 epidermal growth factor receptor pathway substrate 15-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361120, updated on 8-Apr-2026
Symbol
Eps15l1provided by RGD
Full Name
epidermal growth factor receptor pathway substrate 15-like 1provided by RGD
Primary source
RGD:1565708
See related
Ensembl:ENSRNOG00000013502 AllianceGenome:RGD:1565708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in endosomal transport and synaptic vesicle endocytosis. Predicted to be part of clathrin coat of coated pit. Predicted to be active in cytoplasm; plasma membrane; and presynapse. Orthologous to human EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Thymus (RPKM 140.8), Adrenal (RPKM 113.7) and 9 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Eps15l1 in Genome Data Viewer
Location:
16p14
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17460330..17573824)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17426345..17501677)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19127635..19202991)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 19 open reading frame 44 Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene calreticulin 3 Neighboring gene KLF transcription factor 2 Neighboring gene adaptor related protein complex 1 subunit mu 1 Neighboring gene family with sequence similarity 32, member A

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Essential role of cyclin-G-associated kinase (Auxilin-2) in developing and mature mice. Lee DW, et al. Mol Biol Cell, 2008 Jul. PMID 18434600, Free PMC Article
  2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  3. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC116150

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of clathrin coat of coated pit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of clathrin coat of coated pit IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin coat of coated pit ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
epidermal growth factor receptor substrate 15-like 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029921.2 → NP_001025092.1  epidermal growth factor receptor substrate 15-like 1 isoform 4

    See identical proteins and their annotated locations for NP_001025092.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A0G2QC53, A0A8I5ZKJ0
    Related
    ENSRNOP00000078247.2, ENSRNOT00000120186.2
    Conserved Domains (4) summary
    smart00027
    Location:268 → 364
    EH; Eps15 homology domain
    cd00052
    Location:131 → 196
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:398 → 525
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    cl02488
    Location:385 → 566
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  2. NM_001436873.1 → NP_001423802.1  epidermal growth factor receptor substrate 15-like 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6A726, A0A8I6AWN6

  3. NM_001436874.1 → NP_001423803.1  epidermal growth factor receptor substrate 15-like 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I5ZKJ0, D3ZJR1, Q4QQT7

  4. NM_001436875.1 → NP_001423804.1  epidermal growth factor receptor substrate 15-like 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I5ZKJ0, A6K9P6

  5. NM_001436878.1 → NP_001423807.1  epidermal growth factor receptor substrate 15-like 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6AID0

  6. NM_001436879.1 → NP_001423808.1  epidermal growth factor receptor substrate 15-like 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6AID0

  7. NM_001436880.1 → NP_001423809.1  epidermal growth factor receptor substrate 15-like 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6AID0

  8. NM_001436882.1 → NP_001423811.1  epidermal growth factor receptor substrate 15-like 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6AID0

  9. NM_001436883.1 → NP_001423812.1  epidermal growth factor receptor substrate 15-like 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6AID0

  10. NM_001436884.1 → NP_001423813.1  epidermal growth factor receptor substrate 15-like 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6AID0

  11. NM_001436885.1 → NP_001423814.1  epidermal growth factor receptor substrate 15-like 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6AID0

  12. NM_001436886.1 → NP_001423815.1  epidermal growth factor receptor substrate 15-like 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I5ZKJ0

  13. NM_001436887.1 → NP_001423816.1  epidermal growth factor receptor substrate 15-like 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6AID0

  14. NM_001436888.1 → NP_001423817.1  epidermal growth factor receptor substrate 15-like 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6AID0

  15. NM_001436889.1 → NP_001423818.1  epidermal growth factor receptor substrate 15-like 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6AID0

  16. NM_001436891.1 → NP_001423820.1  epidermal growth factor receptor substrate 15-like 1 isoform 17

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

RNA

  1. NR_199185.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  2. NR_199186.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    17460330..17573824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275500.1 → XP_063131570.1  epidermal growth factor receptor substrate 15-like 1 isoform X19

    UniProtKB/TrEMBL
    A0A8I6AID0

  2. XM_063275502.1 → XP_063131572.1  epidermal growth factor receptor substrate 15-like 1 isoform X21

  3. XM_039094619.2 → XP_038950547.1  epidermal growth factor receptor substrate 15-like 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AWN6
    Conserved Domains (3) summary
    smart00027
    Location:268 → 364
    EH; Eps15 homology domain
    COG1196
    Location:385 → 566
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00052
    Location:19 → 85
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...

  4. XM_017600166.3 → XP_017455655.1  epidermal growth factor receptor substrate 15-like 1 isoform X3

    Related
    ENSRNOP00000018960.8, ENSRNOT00000018960.9

  5. XM_017600168.3 → XP_017455657.1  epidermal growth factor receptor substrate 15-like 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AID0

  6. XM_017600169.3 → XP_017455658.1  epidermal growth factor receptor substrate 15-like 1 isoform X6

  7. XM_006252802.5 → XP_006252864.1  epidermal growth factor receptor substrate 15-like 1 isoform X2

    Related
    ENSRNOP00000088897.1, ENSRNOT00000104367.2
    Conserved Domains (4) summary
    smart00027
    Location:268 → 364
    EH; Eps15 homology domain
    cd00052
    Location:131 → 196
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:398 → 525
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    cl02488
    Location:385 → 566
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  8. XM_006252804.5 → XP_006252866.1  epidermal growth factor receptor substrate 15-like 1 isoform X4

    Conserved Domains (4) summary
    smart00027
    Location:268 → 364
    EH; Eps15 homology domain
    cd00052
    Location:131 → 196
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:398 → 525
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    cl02488
    Location:385 → 566
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  9. XM_063275494.1 → XP_063131564.1  epidermal growth factor receptor substrate 15-like 1 isoform X8

    Related
    ENSRNOP00000090770.1, ENSRNOT00000116060.2

  10. XM_063275495.1 → XP_063131565.1  epidermal growth factor receptor substrate 15-like 1 isoform X9

  11. XM_017600167.3 → XP_017455656.1  epidermal growth factor receptor substrate 15-like 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZKJ0

  12. XM_063275497.1 → XP_063131567.1  epidermal growth factor receptor substrate 15-like 1 isoform X14

  13. XM_008771122.4 → XP_008769344.1  epidermal growth factor receptor substrate 15-like 1 isoform X15

    Conserved Domains (4) summary
    smart00027
    Location:268 → 364
    EH; Eps15 homology domain
    cd00052
    Location:131 → 196
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:398 → 525
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    cl23720
    Location:402 → 519
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  14. XM_063275498.1 → XP_063131568.1  epidermal growth factor receptor substrate 15-like 1 isoform X16

    UniProtKB/TrEMBL
    A0A8I6AID0

  15. XM_017600170.3 → XP_017455659.1  epidermal growth factor receptor substrate 15-like 1 isoform X10

  16. XM_017600174.3 → XP_017455663.1  epidermal growth factor receptor substrate 15-like 1 isoform X17

    UniProtKB/TrEMBL
    A0A8I6AID0

  17. XM_039094620.2 → XP_038950548.1  epidermal growth factor receptor substrate 15-like 1 isoform X13

    Conserved Domains (3) summary
    smart00027
    Location:268 → 364
    EH; Eps15 homology domain
    COG1196
    Location:385 → 566
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00052
    Location:19 → 85
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...

  18. XM_063275496.1 → XP_063131566.1  epidermal growth factor receptor substrate 15-like 1 isoform X11

  19. XM_063275499.1 → XP_063131569.1  epidermal growth factor receptor substrate 15-like 1 isoform X18

  20. XM_063275501.1 → XP_063131571.1  epidermal growth factor receptor substrate 15-like 1 isoform X20

  21. XM_017600173.3 → XP_017455662.1  epidermal growth factor receptor substrate 15-like 1 isoform X12

    UniProtKB/TrEMBL
    A0A8I6AID0
Nucleotide Protein Strain
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