U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ILF3 interleukin enhancer binding factor 3 [ Homo sapiens (human) ]

Gene ID: 3609, updated on 5-Aug-2022

Summary

Go to the top of the page Help
Official Symbol
ILF3provided by HGNC
Official Full Name
interleukin enhancer binding factor 3provided by HGNC
Primary source
HGNC:HGNC:6038
See related
Ensembl:ENSG00000129351 MIM:603182; AllianceGenome:HGNC:6038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBTF; DRBF; MMP4; MPP4; NF90; NFAR; NF110; NF90a; NF90b; NF90c; NFAR2; TCP80; DRBP76; NF110b; NFAR-1; NFAR-2; NFAR90; TCP110; MPP4110; NF90ctv; NFAR110; MPHOSPH4; NF-AT-90
Summary
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in bone marrow (RPKM 45.0), testis (RPKM 34.6) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ILF3 in Genome Data Viewer
Location:
19p13.2
Exon count:
23
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10654346..10692400)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10780831..10818864)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10765022..10803076)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 44 member 2 Neighboring gene ILF3 divergent transcript Neighboring gene queuine tRNA-ribosyltransferase catalytic subunit 1 Neighboring gene microRNA 638 Neighboring gene dynamin 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Systematic identification of NF90 target RNAs by iCLIP analysis. Lodde V, et al. Sci Rep, 2022 Jan 10. PMID 35013429, Free PMC Article
  2. Long non-coding RNA ILF3-AS1 facilitates hepatocellular carcinoma progression by stabilizing ILF3 mRNA in an m6A-dependent manner. Bo C, et al. Hum Cell, 2021 Nov. PMID 34491544
  3. NF90 modulates processing of a subset of human pri-miRNAs. Grasso G, et al. Nucleic Acids Res, 2020 Jul 9. PMID 32427329, Free PMC Article
  4. ILF3 promotes gastric cancer proliferation and may be used as a prognostic marker. Liu Y, et al. Mol Med Rep, 2019 Jul. PMID 31115508, Free PMC Article
  5. NF90 regulation of immune factor expression in response to malaria antigens. Idda ML, et al. Cell Cycle, 2019 Mar - Apr. PMID 30784348,

See all (330) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ILF3 represses repeat-derived microRNAs targeting RIG-I mediated type I interferon response.
    Title: ILF3 represses repeat-derived microRNAs targeting RIG-I mediated type I interferon response.
  2. ILF3 is responsible for hyperlipidemia-induced arteriosclerotic calcification by mediating BMP2 and STAT1 transcription.
    Title: ILF3 is responsible for hyperlipidemia-induced arteriosclerotic calcification by mediating BMP2 and STAT1 transcription.
  3. Systematic identification of NF90 target RNAs by iCLIP analysis.
    Title: Systematic identification of NF90 target RNAs by iCLIP analysis.
  4. Long non-coding RNA ILF3-AS1 facilitates hepatocellular carcinoma progression by stabilizing ILF3 mRNA in an m(6)A-dependent manner.
    Title: Long non-coding RNA ILF3-AS1 facilitates hepatocellular carcinoma progression by stabilizing ILF3 mRNA in an m<sup>6</sup>A-dependent manner.
  5. Upregulated long noncoding RNA LincIN promotes tumor progression via the regulation of nuclear factor 90/microRNA7/HOXB13 in esophageal squamous cell carcinoma.
    Title: Upregulated long non‑coding RNA LincIN promotes tumor progression via the regulation of nuclear factor 90/microRNA‑7/HOXB13 in esophageal squamous cell carcinoma.
  6. HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA.
    Title: HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA.
  7. circACTA2 mediates Ang II-induced VSMC senescence by modulation of the interaction of ILF3 with CDK4 mRNA.
    Title: circACTA2 mediates Ang II-induced VSMC senescence by modulation of the interaction of ILF3 with CDK4 mRNA.
  8. TMEM98 mRNA promotes proliferation and invasion of gastric cells by directly interacting with NF90 protein.
    Title: TMEM98 mRNA promotes proliferation and invasion of gastric cells by directly interacting with NF90 protein.
  9. ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer.
    Title: ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer.
  10. NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay.
    Title: NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay.
Submit: New GeneRIF Correction See all GeneRIFs (75)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify interleukin enhancer binding factor 3 (ILF3, NF90), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify interleukin enhancer binding factor 3 (ILF3, NF90), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify interleukin enhancer binding factor 3 (ILF3, NF90), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify interleukin enhancer binding factor 3 (ILF3, NF90), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, interleukin enhancer binding factor 3 (ILF3), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with ILF3 is increased by RRE PubMed
rev NF90 inhibits HIV-1 Rev-dependent activity by interfering with the RNA export function of Rev PubMed
rev NF90-RRE-RNA interaction alters HIV-1 Rev subcellular localization PubMed
rev Three specific domains (residues 89-123, 405-593, and 594-670) of NF90 promote Rev-RRE mediated nuclear export of Gag mRNA, which is dependent on CRM1 function PubMed
rev The C-terminal 67 amino acids (604-671) of NF90 interact with HIV-1 Rev PubMed
Tat tat NF90ctv-TAR RNA interaction shows significant inhibition of Tat-transactivation of the HIV-1 LTR in cells expressing NF90ctv, as well as changes in histone H3 methylation of HIV chromatin PubMed
tat The C-terminal variant of nuclear factor 90 (NF90ctv) with strong affinity for HIV-1 TAR RNA, competes with Tat/TAR interaction in vitro PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of interleukin enhancer binding factor 3 (ILF3, NF90) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
capsid gag Expression of NF90 drastically reduces the amount of p24 expression, suggesting inhibition of HIV-1 particle production PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of viral genome replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region HDA PubMed 
located_in membrane HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
interleukin enhancer-binding factor 3
Names
M phase phosphoprotein 4, nuclear factor associated with DS RNA
M-phase phosphoprotein 4
double-stranded RNA-binding protein, 76 kD
dsRNA binding protein NFAR-2/MPP4
interleukin enhancer binding factor 3, 90kD
interleukin enhancer binding factor 3, 90kDa
nuclear factor associated with dsRNA
nuclear factor of activated T-cells 110 kDa
nuclear factor of activated T-cells 90 kDa
nuclear factor of activated T-cells, 90 kD
translational control protein 80

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029220.1 RefSeqGene

    Range
    5001..43159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001137673.2 → NP_001131145.1  interleukin enhancer-binding factor 3 isoform e

    See identical proteins and their annotated locations for NP_001131145.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and coding region compared to variant 4. The resulting isoform (e) has a distinct C-terminus compared to isoform d. Variants 5 and 19-21 all encode the same isoform (e).
    Source sequence(s)
    AC011475, AW576353, BC064836
    Consensus CDS
    CCDS45967.1
    UniProtKB/Swiss-Prot
    Q12906
    Related
    ENSP00000384660.2, ENST00000407004.7
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:524 → 595
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  2. NM_001394808.1 → NP_001381737.1  interleukin enhancer-binding factor 3 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:524 → 595
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  3. NM_001394809.1 → NP_001381738.1  interleukin enhancer-binding factor 3 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:524 → 595
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  4. NM_001394810.1 → NP_001381739.1  interleukin enhancer-binding factor 3 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:524 → 595
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  5. NM_001394811.1 → NP_001381740.1  interleukin enhancer-binding factor 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC011475
    UniProtKB/Swiss-Prot
    Q9UNA2
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:520 → 591
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  6. NM_001394812.1 → NP_001381741.1  interleukin enhancer-binding factor 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC011475
    UniProtKB/Swiss-Prot
    Q9UNA2
    Related
    ENSP00000468156.1, ENST00000590261.5
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:520 → 591
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  7. NM_001394813.1 → NP_001381742.1  interleukin enhancer-binding factor 3 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:524 → 595
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  8. NM_001394814.1 → NP_001381743.1  interleukin enhancer-binding factor 3 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:520 → 591
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  9. NM_001394815.1 → NP_001381744.1  interleukin enhancer-binding factor 3 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:524 → 595
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  10. NM_001394816.1 → NP_001381745.1  interleukin enhancer-binding factor 3 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:524 → 595
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  11. NM_001394817.1 → NP_001381746.1  interleukin enhancer-binding factor 3 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:520 → 591
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  12. NM_001394818.1 → NP_001381747.1  interleukin enhancer-binding factor 3 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:524 → 595
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  13. NM_001394819.1 → NP_001381748.1  interleukin enhancer-binding factor 3 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:520 → 591
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  14. NM_001394820.1 → NP_001381749.1  interleukin enhancer-binding factor 3 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:520 → 591
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  15. NM_001394821.1 → NP_001381750.1  interleukin enhancer-binding factor 3 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:524 → 595
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  16. NM_001394822.1 → NP_001381751.1  interleukin enhancer-binding factor 3 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:524 → 595
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  17. NM_001394823.1 → NP_001381752.1  interleukin enhancer-binding factor 3 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Related
    ENSP00000465515.1, ENST00000592763.5
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:524 → 595
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  18. NM_001394824.1 → NP_001381753.1  interleukin enhancer-binding factor 3 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:520 → 591
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  19. NM_001394826.1 → NP_001381755.1  interleukin enhancer-binding factor 3 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:520 → 591
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  20. NM_001394827.1 → NP_001381756.1  interleukin enhancer-binding factor 3 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC011475
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:524 → 595
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  21. NM_004516.4 → NP_004507.2  interleukin enhancer-binding factor 3 isoform b

    See identical proteins and their annotated locations for NP_004507.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 4. The resulting isoform (b) has a distinct C-terminus compared to isoform d. This isoform is also called NFAR-1 or DRBP76. Variants 2, 22, and 24 all encode the same isoform (b).
    Source sequence(s)
    AJ271745, AJ271747, DC320902, X98264
    Consensus CDS
    CCDS12247.1
    UniProtKB/Swiss-Prot
    Q12906
    Related
    ENSP00000465219.1, ENST00000589998.5
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:520 → 591
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  22. NM_012218.4 → NP_036350.2  interleukin enhancer-binding factor 3 isoform a

    See identical proteins and their annotated locations for NP_036350.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region compared to variant 4. The resulting isoform (a) has a shorter C-terminus compared to isoform d. This isoform is also called NFAR-2, ILF3-E and NF110. Variants 1, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    AF167570, AJ271747, DC320902, X98264
    Consensus CDS
    CCDS12246.1
    UniProtKB/Swiss-Prot
    Q12906, Q9UNA2
    UniProtKB/TrEMBL
    A0A024R7C7
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:520 → 591
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  23. NM_017620.3 → NP_060090.2  interleukin enhancer-binding factor 3 isoform d

    See identical proteins and their annotated locations for NP_060090.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (d). Variants 4 and 6-8 all encode the same isoform (d).
    Source sequence(s)
    AF167570, AJ271744, AJ271747, BC064836, DC320902
    Consensus CDS
    CCDS45965.1
    UniProtKB/Swiss-Prot
    Q12906
    Related
    ENSP00000468181.1, ENST00000588657.6
    Conserved Domains (3) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    cd19910
    Location:399 → 470
    DSRM_ILF3_rpt1; first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
    cd19912
    Location:524 → 595
    DSRM_ILF3_rpt2; second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins

  24. NM_153464.3 → NP_703194.1  interleukin enhancer-binding factor 3 isoform c

    See identical proteins and their annotated locations for NP_703194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding region compared to variant 4. The resulting isoform (c) has a distinct C-terminus compared to isoform d. This isoform is also called DRBP76 delta and ILF3-C.
    Source sequence(s)
    AJ271745, AJ271746, AJ271747, DC320902, X98264
    Consensus CDS
    CCDS45966.1
    UniProtKB/Swiss-Prot
    Q12906
    Related
    ENSP00000250241.8, ENST00000250241.12
    Conserved Domains (2) summary
    smart00572
    Location:88 → 342
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00358
    Location:402 → 466
    DSRM; Double-stranded RNA binding motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    10654346..10692400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438779.1 → XP_047294735.1  interleukin enhancer-binding factor 3 isoform X1

  2. XM_047438778.1 → XP_047294734.1  interleukin enhancer-binding factor 3 isoform X1

  3. XM_047438780.1 → XP_047294736.1  interleukin enhancer-binding factor 3 isoform X2

  4. XM_047438781.1 → XP_047294737.1  interleukin enhancer-binding factor 3 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    10780831..10818864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001394825.1: Suppressed sequence

    Description
    NM_001394825.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12906.3 GenPept UniProtKB/Swiss-Prot:Q12906

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous