Pnpt1 polyribonucleotide nucleotidyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pnpt1provided by RGD
Official Full Name: polyribonucleotide nucleotidyltransferase 1provided by RGD
Primary source: RGD:1307987
See related: Ensembl:ENSRNOG00000003600 AllianceGenome:RGD:1307987
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables polyribonucleotide nucleotidyltransferase activity. Involved in several processes, including liver regeneration; response to cAMP; and response to growth hormone. Located in endoplasmic reticulum membrane and ribosome. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 70; combined oxidative phosphorylation deficiency 13; and spinocerebellar ataxia type 25. Orthologous to human PNPT1 (polyribonucleotide nucleotidyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Thymus (RPKM 161.7), Heart (RPKM 160.6) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 14q22

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (107078486..107109628)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (102877553..102908696)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (113530470..113561645)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH126190 (e-PCR)
- UniSTS:162898

RH139981 (e-PCR)
- UniSTS:222063

RH144616 (e-PCR)
- UniSTS:233861

RH141211 (e-PCR)
- UniSTS:223207

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5'-RNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	IEA Inferred from Electronic Annotation more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(G) binding	IEA Inferred from Electronic Annotation more info
enables poly(G) binding	ISO Inferred from Sequence Orthology more info
enables poly(U) RNA binding	IEA Inferred from Electronic Annotation more info
enables poly(U) RNA binding	ISO Inferred from Sequence Orthology more info
enables polyribonucleotide nucleotidyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables polyribonucleotide nucleotidyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables polyribonucleotide nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables polyribonucleotide nucleotidyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in RNA import into mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in RNA import into mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interferon-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial RNA 3'-end processing	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial RNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial RNA 5'-end processing	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial RNA 5'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial RNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial mRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial mRNA polyadenylation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial mRNA polyadenylation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in nuclear polyadenylation-dependent mRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in nuclear polyadenylation-dependent mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial RNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in rRNA import into mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in rRNA import into mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular respiration	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular senescence	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial degradosome	IEA Inferred from Electronic Annotation more info
part_of mitochondrial degradosome	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in ribosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: polyribonucleotide nucleotidyltransferase 1, mitochondrial

NP_001135843.1

EC 2.7.7.8

XP_038948164.1

EC 2.7.7.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142371.1 → NP_001135843.1 polyribonucleotide nucleotidyltransferase 1, mitochondrial

See identical proteins and their annotated locations for NP_001135843.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0ABK0LSR5, A6JQA4, G3V6G7

Related

ENSRNOP00000004919.5, ENSRNOT00000004919.7

Conserved Domains (1) summary

PRK11824
Location:47 → 752

PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

107078486..107109628

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092236.2 → XP_038948164.1 polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1

Conserved Domains (1) summary

PRK11824
Location:11 → 590

PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional