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Ogdh oxoglutarate dehydrogenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 360975, updated on 26-Sep-2017
Official Symbol
Ogdhprovided by RGD
Official Full Name
oxoglutarate dehydrogenaseprovided by RGD
Primary source
RGD:1561359
See related
Ensembl:ENSRNOG00000005130
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Location:
14q21
Exon count:
25
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86414924..86481903)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (87376110..87442862)

Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene NPC1 like intracellular cholesterol transporter 1 Neighboring gene ribosome biogenesis protein NSA2 homolog pseudogene Neighboring gene transmembrane p24 trafficking protein 4 Neighboring gene zinc finger MIZ domain-containing protein 2 Neighboring gene 2-oxoglutarate dehydrogenase, mitochondrial-like

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxoglutarate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
oxoglutarate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
PubMed 
oxoglutarate dehydrogenase (succinyl-transferring) activity IDA
Inferred from Direct Assay
more info
PubMed 
oxoglutarate dehydrogenase (succinyl-transferring) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
thiamine pyrophosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
2-oxoglutarate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
NADH metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cerebellar cortex development IEA
Inferred from Electronic Annotation
more info
 
cerebellar cortex development ISO
Inferred from Sequence Orthology
more info
PubMed 
generation of precursor metabolites and energy ISS
Inferred from Sequence or Structural Similarity
more info
 
glycolytic process IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
hippocampus development ISO
Inferred from Sequence Orthology
more info
PubMed 
olfactory bulb mitral cell layer development IEA
Inferred from Electronic Annotation
more info
 
olfactory bulb mitral cell layer development ISO
Inferred from Sequence Orthology
more info
PubMed 
pyramidal neuron development IEA
Inferred from Electronic Annotation
more info
 
pyramidal neuron development ISO
Inferred from Sequence Orthology
more info
PubMed 
striatum development IEA
Inferred from Electronic Annotation
more info
 
striatum development ISO
Inferred from Sequence Orthology
more info
PubMed 
succinyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
tangential migration from the subventricular zone to the olfactory bulb IEA
Inferred from Electronic Annotation
more info
 
tangential migration from the subventricular zone to the olfactory bulb ISO
Inferred from Sequence Orthology
more info
PubMed 
thalamus development IEA
Inferred from Electronic Annotation
more info
 
thalamus development ISO
Inferred from Sequence Orthology
more info
PubMed 
tricarboxylic acid cycle IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NOT cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
oxoglutarate dehydrogenase complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
2-oxoglutarate dehydrogenase, mitochondrial
Names
2-oxoglutarate dehydrogenase E1 component, mitochondrial
2-oxoglutarate dehydrogenase complex component E1
OGDC-E1
alpha-ketoglutarate dehydrogenase
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
oxoglutarate dehydrogenase (lipoamide)
NP_001017461.1
XP_006251508.1
XP_006251509.1
XP_006251510.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017461.1NP_001017461.1  2-oxoglutarate dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001017461.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083811
    UniProtKB/Swiss-Prot
    Q5XI78
    Related
    ENSRNOP00000054026.2, ENSRNOT00000057199.4
    Conserved Domains (5) summary
    PRK09404
    Location:491015
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:264527
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:649864
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16078
    Location:4782
    2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
    pfam16870
    Location:8711014
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

    Range
    86414924..86481903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251448.3XP_006251510.1  2-oxoglutarate dehydrogenase, mitochondrial isoform X2

    Conserved Domains (5) summary
    PRK09404
    Location:491011
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:260523
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:645860
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16078
    Location:4782
    2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
    pfam16870
    Location:8671010
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
  2. XM_006251446.3XP_006251508.1  2-oxoglutarate dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006251508.1

    UniProtKB/Swiss-Prot
    Q5XI78
    Conserved Domains (5) summary
    PRK09404
    Location:491015
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:264527
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:649864
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16078
    Location:4782
    2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
    pfam16870
    Location:8711014
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
  3. XM_006251447.2XP_006251509.1  2-oxoglutarate dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006251509.1

    UniProtKB/Swiss-Prot
    Q5XI78
    Conserved Domains (5) summary
    PRK09404
    Location:491015
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:264527
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:649864
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16078
    Location:4782
    2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
    pfam16870
    Location:8711014
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
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