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Ablim2 actin binding LIM protein family, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360958, updated on 8-Feb-2025

Summary

Official Symbol
Ablim2provided by RGD
Official Full Name
actin binding LIM protein family, member 2provided by RGD
Primary source
RGD:1303094
See related
EnsemblRapid:ENSRNOG00000007882 AllianceGenome:RGD:1303094
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in lamellipodium assembly. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in myofibril. Predicted to be active in actin cytoskeleton. Orthologous to human ABLIM2 (actin binding LIM protein family member 2). [provided by Alliance of Genome Resources, Feb 2025]
Expression
Biased expression in Muscle (RPKM 135.8), Brain (RPKM 110.6) and 3 other tissues See more
Orthologs
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Genomic context

See Ablim2 in Genome Data Viewer
Location:
14q21
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (79090046..79214986, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (74865409..74990334, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (80044217..80169491, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene actin filament associated protein 1 Neighboring gene uncharacterized LOC134481856 Neighboring gene uncharacterized LOC134481855 Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene HtrA serine peptidase 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
actin-binding LIM protein 2
Names
abLIM-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001514.2NP_001001514.1  actin-binding LIM protein 2 isoform b

    See identical proteins and their annotated locations for NP_001001514.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame two-exon segment in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AJ703893
    UniProtKB/TrEMBL
    A0A140TAH7
    Related
    ENSRNOP00000070221.3, ENSRNOT00000091652.3
    Conserved Domains (6) summary
    cd09327
    Location:2475
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:80135
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:153204
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:212267
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam02209
    Location:539573
    VHP; Villin headpiece domain
    pfam16182
    Location:277537
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
  2. NM_001177695.1NP_001171166.1  actin-binding LIM protein 2 isoform a

    See identical proteins and their annotated locations for NP_001171166.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AJ703892
    UniProtKB/Swiss-Prot
    Q6KC50, Q6KC51
    UniProtKB/TrEMBL
    A0A140TAH7
    Related
    ENSRNOP00000055116.6, ENSRNOT00000058315.7
    Conserved Domains (6) summary
    cd09327
    Location:2475
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:80135
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:153204
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:212267
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam02209
    Location:578612
    VHP; Villin headpiece domain
    pfam16182
    Location:277576
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    79090046..79214986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273369.1XP_063129439.1  actin-binding LIM protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A0H2UHF9
  2. XM_063273367.1XP_063129437.1  actin-binding LIM protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A0H2UHF9
  3. XM_063273363.1XP_063129433.1  actin-binding LIM protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JTB5
    Related
    ENSRNOP00000010482.9, ENSRNOT00000010482.9
  4. XM_063273380.1XP_063129450.1  actin-binding LIM protein 2 isoform X18

    UniProtKB/TrEMBL
    A0A0G2JXC7, A0A140TAH7
  5. XM_063273368.1XP_063129438.1  actin-binding LIM protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A140TAH7
  6. XM_063273371.1XP_063129441.1  actin-binding LIM protein 2 isoform X9

    UniProtKB/TrEMBL
    A0A140TAH7
  7. XM_063273377.1XP_063129447.1  actin-binding LIM protein 2 isoform X15

    UniProtKB/TrEMBL
    A0A0G2JTB5
  8. XM_063273378.1XP_063129448.1  actin-binding LIM protein 2 isoform X16

    UniProtKB/TrEMBL
    A0A140TAH7
  9. XM_063273384.1XP_063129454.1  actin-binding LIM protein 2 isoform X21

    UniProtKB/TrEMBL
    A0A140TAH7
  10. XM_063273385.1XP_063129455.1  actin-binding LIM protein 2 isoform X22

    UniProtKB/TrEMBL
    A0A140TAH7
  11. XM_063273374.1XP_063129444.1  actin-binding LIM protein 2 isoform X12

    UniProtKB/TrEMBL
    A0A0G2JTB5
  12. XM_063273362.1XP_063129432.1  actin-binding LIM protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTB5
  13. XM_063273364.1XP_063129434.1  actin-binding LIM protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JTB5
  14. XM_063273381.1XP_063129451.1  actin-binding LIM protein 2 isoform X19

    UniProtKB/TrEMBL
    A0A140TAH7
  15. XM_063273379.1XP_063129449.1  actin-binding LIM protein 2 isoform X17

    UniProtKB/TrEMBL
    A0A140TAH7
  16. XM_063273366.1XP_063129436.1  actin-binding LIM protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A0H2UHF9
  17. XM_063273383.1XP_063129453.1  actin-binding LIM protein 2 isoform X20

    UniProtKB/TrEMBL
    A0A140TAH7
  18. XM_063273372.1XP_063129442.1  actin-binding LIM protein 2 isoform X10

    UniProtKB/TrEMBL
    A0A0G2JTB5
  19. XM_063273376.1XP_063129446.1  actin-binding LIM protein 2 isoform X14

    UniProtKB/TrEMBL
    A0A140TAH7
  20. XM_063273373.1XP_063129443.1  actin-binding LIM protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A0H2UHF9
  21. XM_063273375.1XP_063129445.1  actin-binding LIM protein 2 isoform X13

    UniProtKB/TrEMBL
    A0A0H2UHF9
  22. XM_063273370.1XP_063129440.1  actin-binding LIM protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A0G2JTB5
  23. XM_063273387.1XP_063129457.1  actin-binding LIM protein 2 isoform X24

  24. XM_063273386.1XP_063129456.1  actin-binding LIM protein 2 isoform X23

RNA

  1. XR_010057396.1 RNA Sequence

  2. XR_010057389.1 RNA Sequence

  3. XR_010057397.1 RNA Sequence

  4. XR_010057390.1 RNA Sequence

  5. XR_010057387.1 RNA Sequence

  6. XR_010057388.1 RNA Sequence

  7. XR_010057395.1 RNA Sequence

  8. XR_010057393.1 RNA Sequence

  9. XR_010057392.1 RNA Sequence

  10. XR_010057394.1 RNA Sequence

  11. XR_010057391.1 RNA Sequence