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Esrrg estrogen-related receptor gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 360896, updated on 30-Jul-2025
Official Symbol
Esrrgprovided by RGD
Official Full Name
estrogen-related receptor gammaprovided by RGD
Primary source
RGD:1303236
See related
Ensembl:ENSRNOG00000002593 AllianceGenome:RGD:1303236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
errg
Summary
Predicted to enable several functions, including AF-2 domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and estrogen response element binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to be active in chromatin and nucleus. Orthologous to human ESRRG (estrogen related receptor gamma). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Kidney (RPKM 75.2), Heart (RPKM 50.1) and 6 other tissues See more
Orthologs
human mouse all
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See Esrrg in Genome Data Viewer
Location:
13q26
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (101699043..102316877)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (99167656..99788016)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (106063799..106683353)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553391 Neighboring gene large ribosomal subunit protein eL29-like Neighboring gene uncharacterized LOC120096194 Neighboring gene uncharacterized LOC120096195 Neighboring gene uncharacterized LOC120096344 Neighboring gene usherin Neighboring gene small nucleolar RNA SNORA17

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Estrogen receptor-related receptor gamma has an exceptionally broad specificity of DNA sequence recognition. Razzaque MA, et al. Gene, 2004 Oct 13. PMID 15475169
  2. Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. Zhang Y, et al. J Biol Chem, 2006 Dec 29. PMID 17079227
  3. Requirements for transcriptional regulation by the orphan nuclear receptor ERRgamma. Huppunen J, et al. Mol Cell Endocrinol, 2004 Apr 30. PMID 15149736
  4. Role of Estrogen-Related Receptor γ and PGC-1α/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage. Guo Y, et al. Neurotherapeutics, 2023 Apr. PMID 36481985, Free PMC Article
  5. ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes. Dixen K, et al. Obesity (Silver Spring), 2013 Mar. PMID 23404793

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of Estrogen-Related Receptor gamma and PGC-1alpha/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage.
    Title: Role of Estrogen-Related Receptor γ and PGC-1α/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage.
  2. ERRgamma plays a key role in vascular calcification by upregulating the BMP2 signaling pathway.
    Title: Estrogen-Related Receptor γ Plays a Key Role in Vascular Calcification Through the Upregulation of BMP2 Expression.
  3. ERRgamma was preferentially expressed in brown compared to white fat depots, and ERRgamma was induced during cold-induced browning of subcutaneous white adipose tissue and brown adipogenesis
    Title: ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes.
  4. Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling
    Title: Estrogen-related receptor γ (ERRγ) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling.
  5. ERRgamma recognizes a tremendously broad range of sequences as a homodimer.
    Title: Estrogen receptor-related receptor gamma has an exceptionally broad specificity of DNA sequence recognition.
  6. Estrogen-related receptor gamma binds to the hepatic pyruvate dehydrogenase kinase (PDK) 4 promoter and stimulates PDK4 expression.
    Title: Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables AF-2 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables estrogen response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables estrogen response element binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nuclear receptor-mediated steroid hormone signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of macromolecule biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
estrogen-related receptor gamma
Names
estrogen receptor-related protein 3
nuclear receptor subfamily 3 group B member 3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401443.1 → NP_001388372.1  estrogen-related receptor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    P62510, Q5QJE4, Q75T51, Q75T52
    UniProtKB/TrEMBL
    A0A8I6A6X6, A6JGT8
    Related
    ENSRNOP00000003489.3, ENSRNOT00000003489.7

  2. NM_001415123.1 → NP_001402052.1  estrogen-related receptor gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6A6X6, A6JGU0
    Related
    ENSRNOP00000087260.2, ENSRNOT00000095864.3

  3. NM_001415124.1 → NP_001402053.1  estrogen-related receptor gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6A6X6, A6JGU0

  4. NM_203336.3 → NP_976081.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_976081.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6A6X6, A6JGU0
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    101699043..102316877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272510.1 → XP_063128580.1  estrogen-related receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6X6, A6JGU0

  2. XM_017598866.3 → XP_017454355.1  estrogen-related receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6X6, A6JGU0
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  3. XM_039090940.2 → XP_038946868.1  estrogen-related receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6X6, A6JGU0
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  4. XM_063272511.1 → XP_063128581.1  estrogen-related receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6X6, A6JGU0

  5. XM_063272509.1 → XP_063128579.1  estrogen-related receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6X6, A6JGU0

  6. XM_063272508.1 → XP_063128578.1  estrogen-related receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6X6, A6JGU0

  7. XM_039090941.2 → XP_038946869.1  estrogen-related receptor gamma isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6X6, A6JGU0
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62510.1 GenPept UniProtKB/Swiss-Prot:P62510

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