U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fam162a family with sequence similarity 162, member A [ Rattus norvegicus (Norway rat) ]

Gene ID: 360721, updated on 5-Sep-2025
Official Symbol
Fam162aprovided by RGD
Official Full Name
family with sequence similarity 162, member Aprovided by RGD
Primary source
RGD:1590883
See related
Ensembl:ENSRNOG00000002255 AllianceGenome:RGD:1590883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including cellular response to hypoxia; neuron apoptotic process; and positive regulation of release of cytochrome c from mitochondria. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human FAM162A (family with sequence similarity 162 member A). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Heart (RPKM 1534.1), Muscle (RPKM 486.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See Fam162a in Genome Data Viewer
Location:
11q22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (78186260..78215186)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (64680978..64709865)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (67618683..67646253)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481076 Neighboring gene ribosomal protein S2, pseudogene 8 Neighboring gene RAN binding protein 1 like 1 Neighboring gene mitochondrial matrix import factor 23 Neighboring gene WD repeat domain 5B Neighboring gene karyopherin subunit alpha 1 Neighboring gene uncharacterized LOC134481077

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. A role for ID repetitive sequences in growth- and transformation-dependent regulation of gene expression in rat fibroblasts. Glaichenhaus N, et al. Cell, 1987 Sep 25. PMID 3040268
  2. mHGTD-P mediates hypoxic neuronal cell death via the release of apoptosis-inducing factor. Cho YE, et al. Neurosci Lett, 2007 Apr 12. PMID 17316997
  3. Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Lee MJ, et al. Mol Cell Biol, 2004 May. PMID 15082785, Free PMC Article
  4. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC116101

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of release of cytochrome c from mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of release of cytochrome c from mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein FAM162A
Names
E2-induced gene 5 protein homolog
growth and transformation-dependent protein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399276.2 → NP_001386205.1  protein FAM162A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    Q4QQV3
    UniProtKB/TrEMBL
    A0A8I6AP17, A6IRE2
    Related
    ENSRNOP00000096204.2, ENSRNOT00000099640.2
    Conserved Domains (1) summary
    pfam06388
    Location:16 → 134
    DUF1075; Protein of unknown function (DUF1075)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    78186260..78215186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270641.1 → XP_063126711.1  protein FAM162A isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZR27
    Related
    ENSRNOP00000081032.1, ENSRNOT00000116350.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001029903.1: Suppressed sequence

    Description
    NM_001029903.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4QQV3.1 GenPept UniProtKB/Swiss-Prot:Q4QQV3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools