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Rab34 RAB34, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

Gene ID: 360571, updated on 5-Jan-2022

Summary

Official Symbol
Rab34provided by RGD
Official Full Name
RAB34, member RAS oncogene familyprovided by RGD
Primary source
RGD:1305058
See related
Ensembl:ENSRNOG00000023375
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including GTP-dependent protein binding activity; GTPase activity; and small GTPase binding activity. Involved in cellular response to glucose stimulus and positive regulation of protein secretion. Predicted to be located in several cellular components, including Golgi cisterna; cytoplasmic vesicle; and ruffle. Orthologous to human RAB34 (RAB34, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Kidney (RPKM 221.7), Adrenal (RPKM 141.1) and 9 other tissues See more
Orthologs
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Genomic context

See Rab34 in Genome Data Viewer
Location:
10q25
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63083319..63087538)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65448111..65452178)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA Z17 Neighboring gene small nucleolar RNA SNORD42 Neighboring gene ribosomal protein L23a Neighboring gene protein interacting with cyclin A1 Neighboring gene SPT6 homolog, histone chaperone and transcription elongation factor Neighboring gene stromal cell derived factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables guanyl nucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen processing and presentation IEA
Inferred from Electronic Annotation
more info
 
involved_in antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in lysosomal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in lysosome localization IEA
Inferred from Electronic Annotation
more info
 
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in macropinocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in phagosome maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in phagosome maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phagosome-lysosome fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagosome-lysosome fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in phagosome-lysosome fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in phagosome-lysosome fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi cisterna IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
NOT located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Rab-34
Names
RAB34, member of RAS oncogene family
Ras-related protein RAB34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012140.1NP_001012140.1  ras-related protein Rab-34

    See identical proteins and their annotated locations for NP_001012140.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086400
    UniProtKB/Swiss-Prot
    Q5U1Y1
    Related
    ENSRNOP00000036566.7, ENSRNOT00000037016.7
    Conserved Domains (1) summary
    cd04108
    Location:53220
    Rab36_Rab34; Rab GTPase families 34 (Rab34) and 36 (Rab36)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    63083319..63087538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086356.1XP_038942284.1  ras-related protein Rab-34 isoform X2

    Conserved Domains (1) summary
    cl38936
    Location:32198
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_039086357.1XP_038942285.1  ras-related protein Rab-34 isoform X2

    Related
    ENSRNOP00000078018.1, ENSRNOT00000113207.1
    Conserved Domains (1) summary
    cl38936
    Location:32198
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_039086354.1XP_038942282.1  ras-related protein Rab-34 isoform X1

    Conserved Domains (1) summary
    cd04108
    Location:53220
    Rab36_Rab34; Rab GTPase families 34 (Rab34) and 36 (Rab36)
  4. XM_039086355.1XP_038942283.1  ras-related protein Rab-34 isoform X1

    Conserved Domains (1) summary
    cd04108
    Location:53220
    Rab36_Rab34; Rab GTPase families 34 (Rab34) and 36 (Rab36)
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