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Rnf167 ring finger protein 167 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360554, updated on 5-Jan-2022

Summary

Official Symbol
Rnf167provided by RGD
Official Full Name
ring finger protein 167provided by RGD
Primary source
RGD:1305972
See related
Ensembl:ENSRNOG00000003879
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305972
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of cell cycle; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in endomembrane system. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Orthologous to human RNF167 (ring finger protein 167). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Thymus (RPKM 358.0), Spleen (RPKM 279.3) and 9 other tissues See more
Orthologs
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Genomic context

See Rnf167 in Genome Data Viewer
Location:
10q24
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55360603..55364927)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57268331..57272667)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene glycoprotein Ib platelet subunit alpha Neighboring gene solute carrier family 25 member 11 Neighboring gene profilin 1 Neighboring gene enolase 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Clone Names

  • MGC94514

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF167
Names
RING-type E3 ubiquitin transferase RNF167
NP_001008362.1
XP_006246812.1
XP_038942249.1
XP_038942250.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008361.1NP_001008362.1  E3 ubiquitin-protein ligase RNF167 precursor

    See identical proteins and their annotated locations for NP_001008362.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083670
    UniProtKB/Swiss-Prot
    Q5XIL0
    Related
    ENSRNOP00000005242.4, ENSRNOT00000005242.5
    Conserved Domains (2) summary
    cd02123
    Location:20170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    55360603..55364927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246750.4XP_006246812.1  E3 ubiquitin-protein ligase RNF167 isoform X1

    Related
    ENSRNOP00000087224.1, ENSRNOT00000115572.1
    Conserved Domains (2) summary
    cd02123
    Location:1135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:193238
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  2. XM_039086321.1XP_038942249.1  E3 ubiquitin-protein ligase RNF167 isoform X1

    Conserved Domains (2) summary
    cd02123
    Location:1135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:193238
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  3. XM_039086322.1XP_038942250.1  E3 ubiquitin-protein ligase RNF167 isoform X2

    Conserved Domains (3) summary
    cd00162
    Location:109150
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl28883
    Location:149
    PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
    cl17238
    Location:107152
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
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