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Plscr3 phospholipid scramblase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360549, updated on 5-Jan-2022

Summary

Official Symbol
Plscr3provided by RGD
Official Full Name
phospholipid scramblase 3provided by RGD
Primary source
RGD:1307016
See related
Ensembl:ENSRNOG00000027914
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pls3
Summary
Enables calcium ion binding activity and phospholipid scramblase activity. Predicted to be involved in several processes, including cardiolipin biosynthetic process; plasma membrane phospholipid scrambling; and regulation of release of cytochrome c from mitochondria. Predicted to act upstream of or within cellular response to lipopolysaccharide; cholesterol homeostasis; and glucose homeostasis. Located in mitochondrial inner membrane. Colocalizes with mitochondrion. Orthologous to human PLSCR3 (phospholipid scramblase 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Lung (RPKM 56.9), Heart (RPKM 42.6) and 9 other tissues See more
Orthologs
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Genomic context

See Plscr3 in Genome Data Viewer
Location:
10q24
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54566556..54573240)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56452632..56458390)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene neuroligin 2 Neighboring gene transmembrane protein 256 Neighboring gene tyrosine kinase, non-receptor, 1 Neighboring gene transmembrane protein 95 Neighboring gene potassium channel tetramerization domain containing 11

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lead ion binding ISO
Inferred from Sequence Orthology
more info
 
enables lead ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables mercury ion binding ISO
Inferred from Sequence Orthology
more info
 
enables mercury ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables phospholipid scramblase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipid scramblase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipid scramblase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein self-association ISO
Inferred from Sequence Orthology
more info
 
enables protein self-association ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in cardiolipin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiolipin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in plasma membrane phospholipid scrambling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of release of cytochrome c from mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phospholipid scramblase 3
Names
PL scramblase 3
ca(2+)-dependent phospholipid scramblase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012139.2NP_001012139.1  phospholipid scramblase 3

    See identical proteins and their annotated locations for NP_001012139.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098055
    UniProtKB/Swiss-Prot
    Q6QBQ4
    Related
    ENSRNOP00000035566.5, ENSRNOT00000031640.5
    Conserved Domains (1) summary
    pfam03803
    Location:73285
    Scramblase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    54566556..54573240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086319.1XP_038942247.1  phospholipid scramblase 3 isoform X1

    Conserved Domains (1) summary
    pfam03803
    Location:73285
    Scramblase
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