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Tfap4 transcription factor AP-4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360482, updated on 13-Apr-2024

Summary

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Official Symbol
Tfap4provided by RGD
Official Full Name
transcription factor AP-4provided by RGD
Primary source
RGD:1308357
See related
Ensembl:ENSRNOG00000005227 AllianceGenome:RGD:1308357
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tcfap4
Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of macromolecule metabolic process; and regulation of transcription, DNA-templated. Predicted to act upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human TFAP4 (transcription factor AP-4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 12.8), Spleen (RPKM 12.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tfap4 in Genome Data Viewer
Location:
10q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11507242..11525794)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (11001338..11019386)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (11204616..11222975)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095029 Neighboring gene presequence translocase associated motor 16 Neighboring gene GLIS family zinc finger 2 Neighboring gene uncharacterized LOC120095030 Neighboring gene uncharacterized LOC134480651 Neighboring gene sarcalumenin Neighboring gene uncharacterized LOC134480754

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene. Cheng CK, et al. Mol Endocrinol, 2003 Jul. PMID 12663744
  2. Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements. Aranburu A, et al. Biochem J, 2001 Mar 1. PMID 11171123, Free PMC Article
  3. Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Hu YF, et al. Genes Dev, 1990 Oct. PMID 2123466
  4. Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis. Tsujimoto K, et al. J Biol Chem, 2005 Jul 29. PMID 15944155
  5. AP4 encodes a c-MYC-inducible repressor of p21. Jung P, et al. Proc Natl Acad Sci U S A, 2008 Sep 30. PMID 18818310, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables E-box binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation by host of viral transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation by host of viral transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription factor AP-4
Names
transcription factor AP-4 (activating enhancer binding protein 4)
transcription factor AP4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108267.2 → NP_001101737.1  transcription factor AP-4

    See identical proteins and their annotated locations for NP_001101737.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6K4S7, D3ZJT6
    Related
    ENSRNOP00000006979.5, ENSRNOT00000006979.8
    Conserved Domains (1) summary
    cd11419
    Location:46 → 106
    bHLHzip_TFAP4; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    11507242..11525794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086267.2 → XP_038942195.1  transcription factor AP-4 isoform X1

    Conserved Domains (1) summary
    cd11419
    Location:46 → 106
    bHLHzip_TFAP4; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins

  2. XM_006245819.5 → XP_006245881.1  transcription factor AP-4 isoform X2

    See identical proteins and their annotated locations for XP_006245881.1

    Conserved Domains (1) summary
    cl00081
    Location:1 → 46
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  3. XM_017597365.3 → XP_017452854.1  transcription factor AP-4 isoform X2

    Conserved Domains (1) summary
    cl00081
    Location:1 → 46
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  4. XM_006245822.5 → XP_006245884.1  transcription factor AP-4 isoform X2

    See identical proteins and their annotated locations for XP_006245884.1

    Conserved Domains (1) summary
    cl00081
    Location:1 → 46
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  5. XM_039086268.2 → XP_038942196.1  transcription factor AP-4 isoform X2

    Conserved Domains (1) summary
    cl00081
    Location:1 → 46
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  6. XM_006245823.5 → XP_006245885.1  transcription factor AP-4 isoform X2

    See identical proteins and their annotated locations for XP_006245885.1

    Conserved Domains (1) summary
    cl00081
    Location:1 → 46
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

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