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Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360481, updated on 9-Oct-2018

Summary

Official Symbol
Dnaja3provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member A3provided by RGD
Primary source
RGD:1306527
See related
Ensembl:ENSRNOG00000003855
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tid-1
Expression
Biased expression in Heart (RPKM 385.4), Kidney (RPKM 376.1) and 9 other tissues See more
Orthologs

Genomic context

See Dnaja3 in Genome Data Viewer
Location:
10q12
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (11059701..11085186, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (9825059..9850531, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-17-like Neighboring gene heme oxygenase 2 Neighboring gene NmrA like redox sensor 1 Neighboring gene coronin 7 Neighboring gene vasorin Neighboring gene presequence translocase associated motor 16

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
 
GTPase regulator activity ISO
Inferred from Sequence Orthology
more info
 
Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
IkappaB kinase complex binding ISO
Inferred from Sequence Orthology
more info
 
NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
interferon-gamma receptor binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
activation-induced cell death of T cells IEA
Inferred from Electronic Annotation
more info
 
activation-induced cell death of T cells ISO
Inferred from Sequence Orthology
more info
 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cell aging IEA
Inferred from Electronic Annotation
more info
 
cell aging ISO
Inferred from Sequence Orthology
more info
 
mitochondrial DNA replication IEA
Inferred from Electronic Annotation
more info
 
mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
 
mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interferon-gamma-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of programmed cell death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein folding IEA
Inferred from Electronic Annotation
more info
 
protein folding ISO
Inferred from Sequence Orthology
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
response to heat IEA
Inferred from Electronic Annotation
more info
 
response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle acetylcholine-gated channel clustering ISO
Inferred from Sequence Orthology
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
actin filament IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily A member 3, mitochondrial
Names
DnaJ (Hsp40) homolog, subfamily A, member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038595.1NP_001033684.1  dnaJ homolog subfamily A member 3, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001033684.1

    Status: PROVISIONAL

    Source sequence(s)
    AF516338
    UniProtKB/TrEMBL
    Q2UZS7
    Related
    ENSRNOP00000005479.4, ENSRNOT00000005479.5
    Conserved Domains (4) summary
    cd10719
    Location:236296
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:207416
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:90480
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:93155
    DnaJ; DnaJ domain
  2. NM_001038596.1NP_001033685.1  dnaJ homolog subfamily A member 3, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001033685.1

    Status: PROVISIONAL

    Source sequence(s)
    AY077460
    UniProtKB/TrEMBL
    Q2TVU3
    Related
    ENSRNOP00000073217.1, ENSRNOT00000081596.1
    Conserved Domains (4) summary
    cd10719
    Location:236296
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:207416
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:90435
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:93155
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    11059701..11085186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245817.3XP_006245879.1  dnaJ homolog subfamily A member 3, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006245879.1

    UniProtKB/TrEMBL
    A0A0G2K5E4
    Related
    ENSRNOP00000073394.1, ENSRNOT00000085230.1
    Conserved Domains (4) summary
    cd10719
    Location:236296
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:207416
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:90480
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:93155
    DnaJ; DnaJ domain

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    9817864..9842384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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