Usp7 ubiquitin specific peptidase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Usp7provided by RGD
Official Full Name: ubiquitin specific peptidase 7provided by RGD
Primary source: RGD:1306915
See related: Ensembl:ENSRNOG00000025496 AllianceGenome:RGD:1306915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hausp
Summary: Enables cysteine-type deubiquitinase activity and identical protein binding activity. Involved in positive regulation of apoptotic process; protein deubiquitination; and regulation of protein stability. Predicted to be located in XY body and cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in PML body and cytosol. Orthologous to human USP7 (ubiquitin specific peptidase 7). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Spleen (RPKM 367.9), Thymus (RPKM 342.6) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 10q12

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (7335508..7432018)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (6880684..6925355)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (6930462..7019910)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP7 regulates HMOX-1 via deubiquitination to suppress ferroptosis and ameliorate spinal cord injury in rats.
Title: USP7 regulates HMOX-1 via deubiquitination to suppress ferroptosis and ameliorate spinal cord injury in rats.
Inhibition of USP7 suppresses advanced glycation end-induced cell cycle arrest and senescence of human umbilical vein endothelial cells through ubiquitination of p53.
Title: Inhibition of USP7 suppresses advanced glycation end-induced cell cycle arrest and senescence of human umbilical vein endothelial cells through ubiquitination of p53.
Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy.
Title: Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy.
Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion.
Title: Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion.
USP7, negatively regulated by miR-409-5p, aggravates hypoxia-induced cardiomyocyte injury.
Title: USP7, negatively regulated by miR-409-5p, aggravates hypoxia-induced cardiomyocyte injury.
A rat HAUSP from testis was identified and cloned.
Title: Molecular cloning of rHAUSP encoding a deubiquitinating enzyme in rat testis.
Data show that rat HAUSP (rHAUSP, Usp7_predicted) is polyubiquitinated, polyneddylated, and dimerized, and suggest that rHAUSP may function as a dimer or multimer and is also degraded through the proteasome-mediated degradation.
Title: HAUSP, a deubiquitinating enzyme for p53, is polyubiquitinated, polyneddylated, and dimerized.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143229 (e-PCR)
- UniSTS:232476

RH140275 (e-PCR)
- UniSTS:222353

RH65300 (e-PCR)
- UniSTS:48073

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables K48-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables K48-linked deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type deubiquitinase activity	EXP Inferred from Experiment more info	PubMed
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2A deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables histone H2A deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2B deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables histone H2B deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables p53 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA alkylation repair	ISO Inferred from Sequence Orthology more info
involved_in DNA alkylation repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoubiquitinated protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression via chromosomal CpG island methylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression via chromosomal CpG island methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of establishment of protein localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein stability	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in symbiont-mediated disruption of host cell PML body	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in transcription-coupled nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
involved_in transcription-coupled nucleotide-excision repair	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
is_active_in PML body	ISO Inferred from Sequence Orthology more info
located_in XY body	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 7

Names: deubiquitinating enzyme 7; herpes-virus-associated ubiquitin-specific protease; herpesvirus-associated ubiquitin-specific protease; rHAUSP; ubiquitin specific peptidase 7 (herpes virus-associated); ubiquitin specific protease 7 (herpes virus-associated); ubiquitin thioesterase 7; ubiquitin-specific-processing protease 7

NP_001019961.2

EC 3.4.19.12

XP_006245819.1

EC 3.4.19.12

XP_063125353.1

EC 3.4.19.12

XP_063125354.1

EC 3.4.19.12

XP_063125355.1

EC 3.4.19.12

XP_063125356.1

EC 3.4.19.12

XP_063125357.1

EC 3.4.19.12

XP_063125358.1

EC 3.4.19.12

XP_063125359.1

EC 3.4.19.12

XP_063125360.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024790.2 → NP_001019961.2 ubiquitin carboxyl-terminal hydrolase 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q4VSI4

UniProtKB/TrEMBL

A0A8I6AP58

Related

ENSRNOP00000096267.1, ENSRNOT00000100242.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

7335508..7432018

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269283.1 → XP_063125353.1 ubiquitin carboxyl-terminal hydrolase 7 isoform X1

UniProtKB/TrEMBL

F1LM09
XM_063269286.1 → XP_063125356.1 ubiquitin carboxyl-terminal hydrolase 7 isoform X2

UniProtKB/TrEMBL

A0A8I5ZZJ8, F1LM09
XM_063269285.1 → XP_063125355.1 ubiquitin carboxyl-terminal hydrolase 7 isoform X2

UniProtKB/TrEMBL

A0A8I5ZZJ8, F1LM09

Related

ENSRNOP00000083535.1, ENSRNOT00000117646.2
XM_063269284.1 → XP_063125354.1 ubiquitin carboxyl-terminal hydrolase 7 isoform X1

UniProtKB/TrEMBL

F1LM09
XM_063269287.1 → XP_063125357.1 ubiquitin carboxyl-terminal hydrolase 7 isoform X3

UniProtKB/Swiss-Prot

Q4VSI4
XM_063269288.1 → XP_063125358.1 ubiquitin carboxyl-terminal hydrolase 7 isoform X4

UniProtKB/TrEMBL

F1LM09
XM_006245757.5 → XP_006245819.1 ubiquitin carboxyl-terminal hydrolase 7 isoform X5

UniProtKB/TrEMBL

A0A8I6AKU3, F1LM09

Related

ENSRNOP00000093874.1, ENSRNOT00000094143.2

Conserved Domains (5) summary

COG5077
Location:39 → 1084

COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02659
Location:196 → 507

peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd03772
Location:51 → 186

MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...

pfam12436
Location:604 → 849

USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7

pfam14533
Location:859 → 1070

USP7_C2; Ubiquitin-specific protease C-terminal
XM_063269289.1 → XP_063125359.1 ubiquitin carboxyl-terminal hydrolase 7 isoform X6

UniProtKB/TrEMBL

F1LM09
XM_063269290.1 → XP_063125360.1 ubiquitin carboxyl-terminal hydrolase 7 isoform X7