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mapk1 mitogen-activated protein kinase 1 [ Danio rerio (zebrafish) ]

Gene ID: 360144, updated on 9-Sep-2025
Official Symbol
mapk1provided by ZNC
Official Full Name
mitogen-activated protein kinase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030722-2
See related
Ensembl:ENSDARG00000027552 AllianceGenome:ZFIN:ZDB-GENE-030722-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zERK2
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within gastrulation. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including EVL; brain; cardiovascular system; retina; and superficial blastomere. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 13; Parkinson's disease; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See mapk1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 5 NC_133180.1 (13790780..13855053, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 5 NC_007116.7 (13104854..13167120, complement)

Chromosome 5 - NC_133180.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141385767 Neighboring gene yippee-like 1 Neighboring gene uncharacterized LOC141385768 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1F Neighboring gene uncharacterized LOC141385769

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Relative importance of phosphatidylinositol-3 kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK3/1) signaling during maturational steroid-induced meiotic G2-M1 transition in zebrafish oocytes. Das D, et al. Zygote, 2018 Feb. PMID 29229010
  2. Specific activation of ERK pathways by chitin oligosaccharides in embryonic zebrafish cell lines. Snaar-Jagalska BE, et al. Glycobiology, 2003 Oct. PMID 12881410
  3. Fast Dynamic in vivo Monitoring of Erk Activity at Single Cell Resolution in DREKA Zebrafish. Mayr V, et al. Front Cell Dev Biol, 2018. PMID 30320107, Free PMC Article
  4. Sequence and expression analysis of extracellular signal-regulated kinase 1 from flounder (Paralichthys olivaceous). Lee YS, et al. Fish Shellfish Immunol, 2010 Jan. PMID 19804835
  5. Heat stress-induced heat shock protein 70 expression is dependent on ERK activation in zebrafish (Danio rerio) cells. Keller JM, et al. Comp Biochem Physiol A Mol Integr Physiol, 2008 Jul. PMID 18467140, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAPK1 role in the oocyte maturation
    Title: Relative importance of phosphatidylinositol-3 kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK3/1) signaling during maturational steroid-induced meiotic G2-M1 transition in zebrafish oocytes.
  2. Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer.
    Title: Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer.
  3. ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish.
    Title: ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish.
  4. Data define distinct roles for ERK1 and ERK2 in developmental cell migration processes during zebrafish embryogenesis.
    Title: Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.
  5. eena plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 pathway
    Title: eena Promotes myeloid proliferation through stimulating ERK1/2 phosphorylation in zebrafish.
  6. These results demonstrate that induction of Hsp70 in response to heat stress is dependent on ERK activation in Pac2 cells.
    Title: Heat stress-induced heat shock protein 70 expression is dependent on ERK activation in zebrafish (Danio rerio) cells.
  7. ERK1 and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK2 genes involved in cell-migration, mesendoderm differentiation and patterning were identified.
    Title: ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
mitogen-activated protein kinase 1
Names
ERK2
NP_878308.2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182888.2 → NP_878308.2  mitogen-activated protein kinase 1

    See identical proteins and their annotated locations for NP_878308.2

    Status: PROVISIONAL

    Source sequence(s)
    BC050169
    UniProtKB/TrEMBL
    Q7ZW72
    Related
    ENSDARP00000038550.4, ENSDART00000030213.6
    Conserved Domains (2) summary
    smart00220
    Location:34 → 322
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07849
    Location:28 → 362
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133180.1 Reference GRCz12tu Primary Assembly

    Range
    13790780..13855053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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