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oprk1 opioid receptor, kappa 1 [ Danio rerio (zebrafish) ]

Gene ID: 360139, updated on 9-Mar-2023

Summary

Official Symbol
oprk1provided by ZNC
Official Full Name
opioid receptor, kappa 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030729-1
See related
Ensembl:ENSDARG00000006894 AllianceGenome:ZFIN:ZDB-GENE-030729-1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ZFOR3; ZfKOR
Summary
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Orthologs
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Genomic context

See oprk1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (30878073..30887209)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (30895053..30903240)
103 previous assembly Zv9 (GCF_000002035.4) 2 NC_007113.5 (30593440..30601395)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene regulator of G protein signaling 20 Neighboring gene ATPase H+ transporting V1 subunit H Neighboring gene charged multivesicular body protein 5a Neighboring gene BCL2 associated athanogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled opioid receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables dynorphin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled opioid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318780.1NP_001305709.1  kappa-type opioid receptor isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AF285173, BC162455
    UniProtKB/TrEMBL
    A0A8M1P7D3, B3DGN0, Q98U14
    Conserved Domains (2) summary
    pfam00001
    Location:72324
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:67264
    7tm_4; Olfactory receptor
  2. NM_182886.2NP_878306.2  kappa-type opioid receptor isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    AF285173, BC162455
    UniProtKB/TrEMBL
    A0A8M1PCB9, B3DGN0, Q98U14
    Related
    ENSDARP00000022783.4, ENSDART00000009326.5
    Conserved Domains (2) summary
    pfam00001
    Location:72324
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:67264
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    30878073..30887209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163421.4XP_005163478.1  kappa-type opioid receptor isoform X1

    UniProtKB/TrEMBL
    A0A8M2BAU5
    Conserved Domains (2) summary
    pfam00001
    Location:129381
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:124321
    7tm_4; Olfactory receptor