Format

Send to:

Choose Destination

ZBTB41 zinc finger and BTB domain containing 41 [ Homo sapiens (human) ]

Gene ID: 360023, updated on 23-Nov-2021

Summary

Official Symbol
ZBTB41provided by HGNC
Official Full Name
zinc finger and BTB domain containing 41provided by HGNC
Primary source
HGNC:HGNC:24819
See related
Ensembl:ENSG00000177888
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRBZ1; ZNF924
Expression
Ubiquitous expression in thyroid (RPKM 4.8), brain (RPKM 3.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZBTB41 in Genome Data Viewer
Location:
1q31.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (197153682..197201390, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (197122812..197170423, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene coagulation factor XIII B chain Neighboring gene assembly factor for spindle microtubules Neighboring gene septin 14 pseudogene 12 Neighboring gene ATPase H+ transporting accessory protein 2 pseudogene Neighboring gene crumbs cell polarity complex component 1 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
GeneReviews: Not available
Lupus nephritis susceptibility Loci in women with systemic lupus erythematosus.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36199, DKFZp686C06120

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 41
Names
FRBZ1 protein (FRBZ1)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194314.3NP_919290.2  zinc finger and BTB domain-containing protein 41

    See identical proteins and their annotated locations for NP_919290.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the supported protein.
    Source sequence(s)
    AL356315, AL627208
    Consensus CDS
    CCDS30960.1
    UniProtKB/Swiss-Prot
    Q5SVQ8
    Related
    ENSP00000356375.3, ENST00000367405.5
    Conserved Domains (3) summary
    sd00017
    Location:577597
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18226
    Location:66179
    BTB_POZ_ZBTB41; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41)
    pfam00096
    Location:603625
    zf-C2H2; Zinc finger, C2H2 type

RNA

  1. NR_135153.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL356315, AL627208

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    197153682..197201390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509507.3XP_011507809.1  zinc finger and BTB domain-containing protein 41 isoform X2

    Conserved Domains (4) summary
    smart00225
    Location:89173
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:577597
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:77173
    BTB; BTB/POZ domain
    pfam13465
    Location:562586
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017001205.2XP_016856694.1  zinc finger and BTB domain-containing protein 41 isoform X3

    UniProtKB/Swiss-Prot
    Q5SVQ8
    Related
    ENSP00000502173.1, ENST00000467322.1
Support Center