Format

Send to:

Choose Destination

ZBTB41 zinc finger and BTB domain containing 41 [ Homo sapiens (human) ]

Gene ID: 360023, updated on 2-Oct-2018

Summary

Official Symbol
ZBTB41provided by HGNC
Official Full Name
zinc finger and BTB domain containing 41provided by HGNC
Primary source
HGNC:HGNC:24819
See related
Ensembl:ENSG00000177888 Vega:OTTHUMG00000036275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRBZ1; ZNF924
Expression
Ubiquitous expression in thyroid (RPKM 4.8), brain (RPKM 3.7) and 25 other tissues See more
Orthologs

Genomic context

See ZBTB41 in Genome Data Viewer
Location:
1q31.3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (197153682..197201390, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (197122814..197169672, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene coagulation factor XIII B chain Neighboring gene abnormal spindle microtubule assembly Neighboring gene septin 14 pseudogene 12 Neighboring gene ATPase H+ transporting accessory protein 2 pseudogene Neighboring gene crumbs 1, cell polarity complex component Neighboring gene mitochondrial ribosomal protein S21 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Phenotypes

NHGRI GWAS Catalog

Description
Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
NHGRI GWA Catalog
Lupus nephritis susceptibility Loci in women with systemic lupus erythematosus.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36199, DKFZp686C06120

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 41
Names
FRBZ1 protein (FRBZ1)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194314.2NP_919290.2  zinc finger and BTB domain-containing protein 41

    See identical proteins and their annotated locations for NP_919290.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the supported protein.
    Source sequence(s)
    AL627208, AW856335, AY163816, AY336933, BX640886
    Consensus CDS
    CCDS30960.1
    UniProtKB/Swiss-Prot
    Q5SVQ8
    Related
    ENSP00000356375.3, OTTHUMP00000034407, ENST00000367405.4, OTTHUMT00000088249
    Conserved Domains (2) summary
    sd00017
    Location:577597
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:83173
    BTB; BTB/POZ domain

RNA

  1. NR_135153.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK128549, AW388030, AY163816, BC132818, BE890180, BM821756, BX640886, CB243844, CB959136

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    197153682..197201390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446754.1XP_024302522.1  zinc finger and BTB domain-containing protein 41 isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:577597
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:83173
    BTB; BTB/POZ domain
  2. XM_011509507.3XP_011507809.1  zinc finger and BTB domain-containing protein 41 isoform X2

    Conserved Domains (4) summary
    smart00225
    Location:89173
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:577597
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:77173
    BTB; BTB/POZ domain
    pfam13465
    Location:562586
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017001205.2XP_016856694.1  zinc finger and BTB domain-containing protein 41 isoform X3

    UniProtKB/Swiss-Prot
    Q5SVQ8

RNA

  1. XR_002956436.1 RNA Sequence

Support Center