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DPPA3 developmental pluripotency associated 3 [ Homo sapiens (human) ]

Gene ID: 359787, updated on 11-Jun-2021

Summary

Official Symbol
DPPA3provided by HGNC
Official Full Name
developmental pluripotency associated 3provided by HGNC
Primary source
HGNC:HGNC:19199
See related
Ensembl:ENSG00000187569 MIM:608408
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Pgc7; STELLA
Summary
This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See DPPA3 in Genome Data Viewer
Location:
12p13.31
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (7711433..7717559)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7864029..7870155)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 1 Neighboring gene Sharpr-MPRA regulatory region 10898 Neighboring gene growth differentiation factor 3 Neighboring gene C-type lectin domain family 4 member C Neighboring gene NANOG neighbor homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of DNA demethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protection of DNA demethylation of female pronucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protection of DNA demethylation of female pronucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of genetic imprinting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of genetic imprinting ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in female pronucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT located_in male pronucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
developmental pluripotency-associated protein 3
Names
stella-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199286.4NP_954980.1  developmental pluripotency-associated protein 3

    See identical proteins and their annotated locations for NP_954980.1

    Status: REVIEWED

    Source sequence(s)
    AC006517, AY317075
    Consensus CDS
    CCDS8582.1
    UniProtKB/Swiss-Prot
    Q6W0C5
    Related
    ENSP00000339250.2, ENST00000345088.3
    Conserved Domains (1) summary
    pfam15549
    Location:1146
    PGC7_Stella; PGC7/Stella/Dppa3 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    7711433..7717559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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