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RTN4 reticulon 4 [ Bos taurus (domestic cattle) ]

Gene ID: 359718, updated on 5-Sep-2025
Official Symbol
RTN4provided by VGNC
Official Full Name
reticulon 4provided by VGNC
Primary source
VGNC:VGNC:106907
See related
BGD:BT19094; EnsemblRapid:ENSBTAG00070006141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See RTN4 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (37722023..37796530, complement)

Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene spectrin beta, non-erythrocytic 1 Neighboring gene microRNA mir-2296 Neighboring gene microRNA mir-2297 Neighboring gene EMAP like 6 Neighboring gene uncharacterized LOC101902504 Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene clathrin heavy chain linker domain containing 1

Genomic Sequence:
NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Reticulon 4 in chondrocytic cells: barosensitivity and intracellular localization. Sironen RK, et al. Int J Biochem Cell Biol, 2004 Aug. PMID 15147731
  2. A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family. Oertle T, et al. FASEB J, 2003 Jul. PMID 12832288
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC139261

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endoplasmic reticulum tubular network formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
reticulon-4

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075138.2 → NP_001068606.1  reticulon-4 isoform 1

    See identical proteins and their annotated locations for NP_001068606.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 2. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 2.
    Source sequence(s)
    DV848001, EE239996, EE379974, EH165710
    UniProtKB/TrEMBL
    Q7YRW9
    Related
    ENSBTAP00070008236.1, ENSBTAT00070014072.1
    Conserved Domains (1) summary
    pfam02453
    Location:12 → 176
    Reticulon

  2. NM_001113221.2 → NP_001106692.1  reticulon-4 isoform 2

    See identical proteins and their annotated locations for NP_001106692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    BC114748, DV820307, DV848001
    UniProtKB/TrEMBL
    A0AAA9SES1, Q1RMR8
    Related
    ENSBTAP00070008261.1, ENSBTAT00070014143.1
    Conserved Domains (1) summary
    pfam02453
    Location:192 → 356
    Reticulon; Reticulon

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    37722023..37796530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005212571.5 → XP_005212628.1  reticulon-4 isoform X1

    UniProtKB/TrEMBL
    A0AAA9T6F1, F1N405
    Related
    ENSBTAP00070008256.1, ENSBTAT00070014126.1
    Conserved Domains (1) summary
    pfam02453
    Location:1013 → 1177
    Reticulon; Reticulon

  2. XM_024998370.2 → XP_024854138.1  reticulon-4 isoform X2

    UniProtKB/TrEMBL
    A0AAA9SR34
    Conserved Domains (1) summary
    pfam02453
    Location:14 → 178
    Reticulon
Nucleotide Protein Strain
Heading Accession and Version

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Research Materials