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IL13 interleukin 13 [ Homo sapiens (human) ]

Gene ID: 3596, updated on 24-Nov-2020

Summary

Official Symbol
IL13provided by HGNC
Official Full Name
interleukin 13provided by HGNC
Primary source
HGNC:HGNC:5973
See related
Ensembl:ENSG00000169194 MIM:147683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P600; IL-13
Summary
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 13.9) See more
Orthologs

Genomic context

See IL13 in Genome Data Viewer
Location:
5q31.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (132656522..132661110)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (131993865..131996801)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene interleukin 5 Neighboring gene RAD50 double strand break repair protein Neighboring gene Th2 cytokine locus control region Neighboring gene T helper type 2 locus control region associated RNA Neighboring gene uncharacterized LOC105379176 Neighboring gene interleukin 4 Neighboring gene kinesin family member 3A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
GeneReviews: Not available
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.
GeneReviews: Not available
A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.
GeneReviews: Not available
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
GeneReviews: Not available
A large-scale, consortium-based genomewide association study of asthma.
GeneReviews: Not available
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.
GeneReviews: Not available
Allergic rhinitis
MedGen: C2607914 OMIM: 607154 GeneReviews: Not available
Compare labs
Asthma, susceptibility to
MedGen: C1869116 OMIM: 600807 GeneReviews: Not available
Compare labs
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
GeneReviews: Not available
Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups.
GeneReviews: Not available
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces release of IL-13 in CD4+ T cells PubMed
env HIV-1 gp120 induces IL-4 and IL-13 releases from human basophils through its interaction with the VH3 region of IgE PubMed
env HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of IL-13 in peptide-treated PBMCs PubMed
Tat tat HIV-1 Tat induces IL-4 and IL-13 release from basophils, leading to dysregulation of the IgE/Fc epsilon RI network PubMed
reverse transcriptase gag-pol IL-13 can act on macrophages both before and after HIV-1 infection to interfere with virus replication by blocking the completion of reverse transcription, decreasing virus production, and reducing the infectivity of the progeny virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC116786, MGC116788, MGC116789

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-13 receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
macrophage activation IGI
Inferred from Genetic Interaction
more info
PubMed 
microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of NAD(P)H oxidase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of complement-dependent cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of lung ciliated cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transforming growth factor beta production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of connective tissue growth factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of immunoglobulin production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-10 production IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of lung goblet cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pancreatic stellate cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
regulation of proton transport IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to nicotine IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012090.1 RefSeqGene

    Range
    5001..7938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001354991.2NP_001341920.1  interleukin-13 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC004039, AC004041
    Conserved Domains (1) summary
    cl11518
    Location:179
    IL4; Interleukin 4
  2. NM_001354992.2NP_001341921.1  interleukin-13 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC004039, AC004041
    Conserved Domains (1) summary
    cl11518
    Location:179
    IL4; Interleukin 4
  3. NM_001354993.2NP_001341922.1  interleukin-13 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC004039, AC004041
    Conserved Domains (1) summary
    cl11518
    Location:179
    IL4; Interleukin 4
  4. NM_002188.3NP_002179.2  interleukin-13 isoform 1 precursor

    See identical proteins and their annotated locations for NP_002179.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC004039
    Consensus CDS
    CCDS4157.1
    UniProtKB/Swiss-Prot
    P35225
    Related
    ENSP00000304915.3, ENST00000304506.7
    Conserved Domains (1) summary
    pfam03487
    Location:35144
    IL13; Interleukin-13

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    132656522..132661110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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