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alc alicorn [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35931, updated on 2-Nov-2024

Summary

Official Symbol
alcprovided by FlyBase
Official Full Name
alicornprovided by FlyBase
Primary source
FLYBASE:FBgn0260972
Locus tag
Dmel_CG8057
See related
AllianceGenome:FB:FBgn0260972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
8057; AMPK; AMPKbeta; betaAMPK; CG8057; Dmel\CG8057; FBgn0033383; l(2)45Ad
Summary
Predicted to enable protein kinase binding activity. Involved in maintenance of apical/basal cell polarity and neuron cellular homeostasis. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. Orthologous to several human genes including PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See alc in Genome Data Viewer
Location:
45A11-45A11; 2-60 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9135375..9137933, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5022880..5025438, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Suppressor of variegation 2-10 Neighboring gene Glutathione S transferase E13 Neighboring gene uncharacterized protein Neighboring gene alpha/beta hydrolase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene shrub

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in maintenance of apical/basal cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
alicorn
Names
CG8057-PA
CG8057-PB
alc-PA
alc-PB
beta homologue
beta subunit of the SNF1/AMP-activated protein kinase
lethal (2) 45Ad

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9135375..9137933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136616.5NP_610460.1  alicorn, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610460.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7Q8, Q8IGW5
    Related
    FBpp0087705
    Conserved Domains (2) summary
    smart01010
    Location:254341
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:156238
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
  2. NM_206061.2NP_995783.1  alicorn, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995783.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SG9
    Conserved Domains (2) summary
    smart01010
    Location:133220
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:35117
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase