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Phax Phosphorylated adaptor for RNA export [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35926, updated on 4-Jan-2025

Summary

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Official Symbol
Phaxprovided by FlyBase
Official Full Name
Phosphorylated adaptor for RNA exportprovided by FlyBase
Primary source
FLYBASE:FBgn0033380
Locus tag
Dmel_CG8069
See related
AllianceGenome:FB:FBgn0033380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GH22533; CG8069; Dmel\CG8069; dPHAX
Summary
Predicted to enable RNA binding activity. Predicted to be involved in snRNA export from nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human PHAX (phosphorylated adaptor for RNA export). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Phax in Genome Data Viewer
Location:
45A8-45A8; 2-60 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9114274..9116030)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5001779..5003535)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phosphoglucomutase 2a Neighboring gene Mystery 45A Neighboring gene tsunagi Neighboring gene Suppressor of variegation 2-10 Neighboring gene Glutathione S transferase E13 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Allele-specific alternative splicing of Drosophila Ribosomal protein S21 suppresses a lethal mutation in the Phosphorylated adaptor for RNA export (Phax) gene. Garcia EL. G3 (Bethesda), 2022 Aug 25. PMID 35920767, Free PMC Article
  2. Transcriptomic comparison of Drosophila snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy. Garcia EL, et al. RNA, 2016 Aug. PMID 27268418, Free PMC Article
  3. Population genomics of Wolbachia and mtDNA in Drosophila simulans from California. Signor S. Sci Rep, 2017 Oct 17. PMID 29042606, Free PMC Article
  4. A genetic screen to uncover mechanisms underlying lipid transfer protein function at membrane contact sites. Mishra S, et al. Life Sci Alliance, 2024 Jun. PMID 38499328, Free PMC Article
  5. A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs. Huang C, et al. Genes Dev, 2018 May 1. PMID 29773557, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in snRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
phosphorylated adaptor for RNA export
Names
CG8069-PA
CG8069-PB
PHosphorylated adaptor for RNA export
Phax-PA
Phax-PB
similar to PHAX

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9114274..9116030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165644.3 → NP_724748.1  phosphorylated adaptor for RNA export, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724748.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL95
    Related
    FBpp0100001
    Conserved Domains (1) summary
    pfam10258
    Location:147 → 230
    RNA_GG_bind; PHAX RNA-binding domain

  2. NM_136612.4 → NP_610456.4  phosphorylated adaptor for RNA export, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610456.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7P3, Q8SYG4, Q9V537
    Conserved Domains (1) summary
    pfam10258
    Location:243 → 326
    RNA_GG_bind; PHAX RNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7P3 A1Z7P3
Q6NL95 Q6NL95
Q8SYG4 Q8SYG4

Gene LinkOut

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