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IL11RA interleukin 11 receptor subunit alpha [ Homo sapiens (human) ]

Gene ID: 3590, updated on 7-Jun-2020

Summary

Official Symbol
IL11RAprovided by HGNC
Official Full Name
interleukin 11 receptor subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:5967
See related
Ensembl:ENSG00000137070 MIM:600939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRSDA
Summary
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Expression
Ubiquitous expression in heart (RPKM 21.3), skin (RPKM 17.1) and 24 other tissues See more
Orthologs

Genomic context

See IL11RA in Genome Data Viewer
Location:
9p13.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (34652185..34661902)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34652182..34661899)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene sigma non-opioid intracellular receptor 1 Neighboring gene galactose-1-phosphate uridylyltransferase Neighboring gene uncharacterized LOC107987063 Neighboring gene uncharacterized LOC730098 Neighboring gene C-C motif chemokine ligand 27 Neighboring gene C-C motif chemokine ligand 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: GALT

Homology

Clone Names

  • MGC2146

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-11 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-11 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
developmental process IMP
Inferred from Mutant Phenotype
more info
PubMed 
head development IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-11-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-11 receptor subunit alpha
Names
IL-11 receptor subunit alpha
IL-11R subunit alpha
interleukin 11 receptor, alpha
interleukin-11 receptor alpha chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028966.1 RefSeqGene

    Range
    5001..14718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142784.3NP_001136256.1  interleukin-11 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_001136256.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes a functional protein.
    Source sequence(s)
    BC003110, DA917660, Z38102
    Consensus CDS
    CCDS6567.1
    UniProtKB/Swiss-Prot
    Q14626
    UniProtKB/TrEMBL
    Q5VZ79
    Related
    ENSP00000394391.2, ENST00000441545.6
    Conserved Domains (3) summary
    smart00410
    Location:33109
    IG_like; Immunoglobulin like
    cd00063
    Location:218310
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:4095
    Ig; Immunoglobulin domain

RNA

  1. NR_052010.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon, compared to variant 3. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC003110, DC424068, Z38102
    Related
    ENST00000557298.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    34652185..34661902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004512.3: Suppressed sequence

    Description
    NM_004512.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_147162.1: Suppressed sequence

    Description
    NM_147162.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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