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IL10RB interleukin 10 receptor subunit beta [ Homo sapiens (human) ]

Gene ID: 3588, updated on 20-Dec-2019

Summary

Official Symbol
IL10RBprovided by HGNC
Official Full Name
interleukin 10 receptor subunit betaprovided by HGNC
Primary source
HGNC:HGNC:5965
See related
Ensembl:ENSG00000243646 MIM:123889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2
Summary
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 32.9), colon (RPKM 23.4) and 25 other tissues See more
Orthologs

Genomic context

See IL10RB in Genome Data Viewer
Location:
21q22.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (33266367..33297221)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34638665..34669539)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372787 Neighboring gene interferon alpha and beta receptor subunit 2 Neighboring gene IL10RB divergent transcript Neighboring gene interferon alpha and beta receptor subunit 1 Neighboring gene upstream transcription factor 1 pseudogene 1 Neighboring gene interferon gamma receptor 2 Neighboring gene transmembrane protein 50B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Hepatitis b virus, susceptibility to
MedGen: C1864880 OMIM: 610424 GeneReviews: Not available
Compare labs
Inflammatory bowel disease 25, autosomal recessive
MedGen: C2675508 OMIM: 612567 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: IFNAR2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-10 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to interleukin-10 receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
interleukin-28 receptor complex NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-10 receptor subunit beta
Names
IL-10 receptor subunit beta
IL-10R subunit 2
IL-10R subunit beta
IL-10RB
cytokine receptor class-II CRF2-4
cytokine receptor class-II member 4
cytokine receptor family 2 member 4
cytokine receptor family II, member 4
interleukin 10 receptor, beta
interleukin-10 receptor subunit 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012089.1 RefSeqGene

    Range
    4994..35868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_152

mRNA and Protein(s)

  1. NM_000628.5NP_000619.3  interleukin-10 receptor subunit beta precursor

    See identical proteins and their annotated locations for NP_000619.3

    Status: REVIEWED

    Source sequence(s)
    AI025402, AU133530, BC001903, Z17227
    Consensus CDS
    CCDS13623.1
    UniProtKB/Swiss-Prot
    Q08334
    Related
    ENSP00000290200.2, ENST00000290200.7
    Conserved Domains (2) summary
    pfam09294
    Location:111213
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    cl21522
    Location:21100
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    33266367..33297221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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