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IL10RA interleukin 10 receptor subunit alpha [ Homo sapiens (human) ]

Gene ID: 3587, updated on 25-Oct-2020

Summary

Official Symbol
IL10RAprovided by HGNC
Official Full Name
interleukin 10 receptor subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:5964
See related
Ensembl:ENSG00000110324 MIM:146933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1
Summary
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Expression
Broad expression in spleen (RPKM 29.9), bone marrow (RPKM 20.8) and 18 other tissues See more
Orthologs

Genomic context

See IL10RA in Genome Data Viewer
Location:
11q23.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (117986394..118003037)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (117857106..117872198)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FXYD6-FXYD2 readthrough Neighboring gene FXYD domain containing ion transport regulator 6 Neighboring gene transmembrane serine protease 13 Neighboring gene small integral membrane protein 35 Neighboring gene RNA, 7SL, cytoplasmic 828, pseudogene Neighboring gene uncharacterized LOC105369517 Neighboring gene transmembrane serine protease 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Inflammatory bowel disease 28, autosomal recessive
MedGen: C2751053 OMIM: 613148 GeneReviews: Not available
Compare labs
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-10 binding IEA
Inferred from Electronic Annotation
more info
 
interleukin-10 receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synapse organization IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-10 receptor subunit alpha
Names
IL-10 receptor subunit alpha
IL-10R subunit 1
IL-10R subunit alpha
IL-10RA
interleukin 10 receptor, alpha
interleukin-10 receptor alpha chain
interleukin-10 receptor subunit 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016275.1 RefSeqGene

    Range
    5001..20093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_151

mRNA and Protein(s)

  1. NM_001558.4NP_001549.2  interleukin-10 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_001549.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the protein-coding transcript.
    Source sequence(s)
    AK291645, AP002962, BC028082, CA307153
    Consensus CDS
    CCDS8388.1
    UniProtKB/Swiss-Prot
    Q13651
    Related
    ENSP00000227752.3, ENST00000227752.7
    Conserved Domains (2) summary
    pfam01108
    Location:21111
    Tissue_fac; Tissue factor
    cl21522
    Location:129227
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. NR_026691.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate exon compared to variant 1. It is not thought to be protein-coding.
    Source sequence(s)
    AK291645, AK301484, AP002962, BC028082, CA307153

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    117986394..118003037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448493.1XP_024304261.1  interleukin-10 receptor subunit alpha isoform X1

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