pdm3 pou domain motif 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pdm3provided by FlyBase
Official Full Name: pou domain motif 3provided by FlyBase
Primary source: FLYBASE:FBgn0261588
Locus tag: Dmel_CG42698
See related: AllianceGenome:FB:FBgn0261588
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:AT16994; CG11641; CG14755; CG42698; Dmel\CG42698; Pdm3
Old locus tag: Dmel_CG11641; Dmel_CG14755
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in axon guidance; axon target recognition; and sensory perception of smell. Is expressed in several structures, including adult brain cell body rind; adult pars intercerebralis; appendage; chemosensory neurons; and ellipsoid body. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human POU6F1 (POU class 6 homeobox 1) and POU6F2 (POU class 6 homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8327490..8396280)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4214995..4283785)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Identification of a molecular basis for the juvenile sleep state.
Title: Identification of a molecular basis for the juvenile sleep state.
POU domain motif3 (Pdm3) induces wingless (wg) transcription and is essential for development of larval neuromuscular junctions in Drosophila.
Title: POU domain motif3 (Pdm3) induces wingless (wg) transcription and is essential for development of larval neuromuscular junctions in Drosophila.
Our results...establish Pdm3 as a regulator of interoceptive axon targeting.
Title: Diversity of Internal Sensory Neuron Axon Projection Patterns Is Controlled by the POU-Domain Protein Pdm3 in Drosophila Larvae.
POU domain motif 3 (Pdm3) is required in ring (R) neurons to control precise axon targeting to the Drosophila ellipsoid body (EB).
Title: The POU-domain protein Pdm3 regulates axonal targeting of R neurons in the Drosophila ellipsoid body.
This study demonstrates a role for pdm3 in both of the processes that define the functional organization of ORNs in the olfactory system.
Title: A new Drosophila POU gene, pdm3, acts in odor receptor expression and axon targeting of olfactory neurons.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon target recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

Names: CG42698-PA; CG42698-PC; CG42698-PE; CG42698-PF; POU domain motif 3; pdm3-PA; pdm3-PC; pdm3-PE; pdm3-PF

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The following sections contain reference sequences that belong to a specific genome build. Explain